Multifaceted immunomodulatory effects of the BTK inhibitors ibrutinib and acalabrutinib on different immune cell subsets–beyond B lymphocytes

S Zhu, S Gokhale, J Jung, E Spirollari, J Tsai… - Frontiers in cell and …, 2021 - frontiersin.org
The clinical success of the two BTK inhibitors, ibrutinib and acalabrutinib, represents a major
breakthrough in the treatment of chronic lymphocytic leukemia (CLL) and has also …

Clinical trials of the BTK inhibitors ibrutinib and acalabrutinib in human diseases beyond B cell malignancies

S Zhu, J Jung, E Victor, J Arceo, S Gokhale… - Frontiers in …, 2021 - frontiersin.org
The BTK inhibitors ibrutinib and acalabrutinib are FDA-approved drugs for the treatment of B
cell malignances. Both drugs have demonstrated clinical efficacy and safety profiles superior …

Protective role of 4‐octyl itaconate in murine LPS/D‐GalN‐induced acute liver failure via inhibiting inflammation, oxidative stress, and apoptosis

R Li, W Yang, Y Yin, P Zhang… - Oxidative medicine and …, 2021 - Wiley Online Library
Oxidative stress, inflammation, and apoptosis are crucial in the pathogenesis of acute liver
failure (ALF). 4‐Octyl itaconate (OI) showed antioxidative and anti‐inflammatory properties …

Propitious maneuvering for delivery of the phytopharmaceutical “apocynin” to induced fulminant hepatitis in BALB/c mice: In vitro and in vivo assessments

HM Anter, RM Aman, AA Shaaban, IIA Hashim… - International Journal of …, 2022 - Elsevier
Apocynin (APO), a specific nicotinamide adenine dinucleotide phosphate-oxidase (NADPH-
oxidase, NOX) inhibitor, has recently emerged as a bioactive phytochemical with eminent …

Ingestion of mannose ameliorates thioacetamide-induced intrahepatic oxidative stress, inflammation and fibrosis in rats

ME Shaker, NH Eisa, A Elgaml, A El-Mesery… - Life Sciences, 2021 - Elsevier
Background and aims The monosaccharide mannose has gained recent interest for its
beneficial effect against certain inflammatory disorders. Nevertheless, the influence of …

Emerging roles of tyrosine kinases in hepatic inflammatory diseases and therapeutic opportunities

ME Shaker, HAM Gomaa, MA Abdelgawad… - International …, 2023 - Elsevier
Inflammation has been convicted of causing and worsening many liver diseases like acute
liver failure, fibrosis, cirrhosis, fatty liver and liver cancer. Pattern recognition receptors …

Bruton's tyrosine kinase inhibition limits endotoxic shock by suppressing IL-6 production by marginal zone B cells in mice

K Kawata, S Hatano, A Baba, K Imabayashi… - Frontiers in …, 2024 - frontiersin.org
Sepsis is a systemic inflammatory response to a severe, life-threatening infection with organ
dysfunction. Although there is no effective treatment for this fatal illness, a deeper …

Bruton's tyrosine kinase inhibition suppresses pathological retinal angiogenesis

S Chen, Y Liu, Y Zhang, X Guo, T Bai… - British Journal of …, 2024 - Wiley Online Library
Abstract Background and Purpose Pathological retinal angiogenesis is a typical
manifestation of vision‐threatening ocular diseases. Many patients exhibit poor response or …

Ibrutinib Induces a Dramatic Improvement for Idiopathic Refractory Ascites Following Allogeneic Hematopoietic Cell Transplantation

K Tazoe, M Nishimoto, A Yamamoto, Y Makuuchi… - Internal …, 2023 - jstage.jst.go.jp
We herein report a case of idiopathic refractory ascites following allogeneic hematopoietic
cell transplantation that was successfully treated with ibrutinib. A 39-year-old man presented …