Determinants, maintenance, and function of organellar pH
SA Freeman, S Grinstein… - Physiological reviews, 2023 - journals.physiology.org
The protonation state of soluble and membrane-associated macromolecules dictates their
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …
Folding and misfolding of human membrane proteins in health and disease: from single molecules to cellular proteostasis
Advances over the past 25 years have revealed much about how the structural properties of
membranes and associated proteins are linked to the thermodynamics and kinetics of …
membranes and associated proteins are linked to the thermodynamics and kinetics of …
Protein sorting at the ER–Golgi interface
N Gomez-Navarro, E Miller - Journal of Cell Biology, 2016 - rupress.org
Protein traffic is of critical importance for normal cellular physiology. In eukaryotes, spherical
transport vesicles move proteins and lipids from one internal membrane-bound …
transport vesicles move proteins and lipids from one internal membrane-bound …
Cargo capture and bulk flow in the early secretory pathway
C Barlowe, A Helenius - Annual review of cell and …, 2016 - annualreviews.org
Transport of newly synthesized proteins from the endoplasmic reticulum (ER) to the Golgi
complex is highly selective. As a general rule, such transport is limited to soluble and …
complex is highly selective. As a general rule, such transport is limited to soluble and …
[HTML][HTML] Emerging roles of protein disulfide isomerase in cancer
E Lee - BMB reports, 2017 - ncbi.nlm.nih.gov
The protein disulfide isomerase (PDI) family is a group of multifunctional endoplasmic
reticulum (ER) enzymes that mediate the formation of disulfide bonds, catalyze the cysteine …
reticulum (ER) enzymes that mediate the formation of disulfide bonds, catalyze the cysteine …
Assembly and cellular exit of coronaviruses: Hijacking an unconventional secretory pathway from the pre-Golgi intermediate compartment via the Golgi ribbon to the …
Coronaviruses (CoVs) assemble by budding into the lumen of the intermediate compartment
(IC) at the endoplasmic reticulum (ER)-Golgi interface. However, why CoVs have chosen the …
(IC) at the endoplasmic reticulum (ER)-Golgi interface. However, why CoVs have chosen the …
Role of the early secretory pathway in SARS-CoV-2 infection
D Sicari, A Chatziioannou, T Koutsandreas… - Journal of Cell …, 2020 - rupress.org
Similar to other RNA viruses, SARS-CoV-2 must (1) enter a target/host cell,(2) reprogram it
to ensure its replication,(3) exit the host cell, and (4) repeat this cycle for exponential growth …
to ensure its replication,(3) exit the host cell, and (4) repeat this cycle for exponential growth …
Protein quality control in the endoplasmic reticulum
BM Adams, ME Oster, DN Hebert - The protein journal, 2019 - Springer
The site of protein folding and maturation for the majority of proteins that are secreted,
localized to the plasma membrane or targeted to endomembrane compartments is the …
localized to the plasma membrane or targeted to endomembrane compartments is the …
Cysteines as redox molecular switches and targets of disease
A Fra, ED Yoboue, R Sitia - Frontiers in molecular neuroscience, 2017 - frontiersin.org
Thiol groups can undergo numerous modifications, making cysteine a unique molecular
switch. Cysteine plays structural and regulatory roles as part of proteins or glutathione …
switch. Cysteine plays structural and regulatory roles as part of proteins or glutathione …
Controlling entropy to tune the functions of intrinsically disordered regions
Highlights•High entropy of intrinsically disordered regions (IDRs) forms the basis for
functional plasticity.•Inherent features of IDRs are optimised to overcome the entropic cost of …
functional plasticity.•Inherent features of IDRs are optimised to overcome the entropic cost of …