The use of nitroglycerin in the treatment of angina pectoris began not long after its original
synthesis in 1847. Since then, the discovery of nitric oxide as a biological effector and better …

In retrospect, basic research in the fields of nitric oxide (NO) and cyclic guanosine
monophosphate (cGMP) during the past two decades appears to have followed a logical …

Objectives: We sought to compare the in-hospital mortality of patients with acute
decompensated heart failure (ADHF) who were receiving parenteral treatment with one of …

In retrospect, basic research in the fields of NO and cyclic GMP during thev past two
decades appears to have followed a logical course beginning with the findings that NO and …

Background Intravenous infusion of nesiritide, a brain (B-type) natriuretic peptide, has
beneficial hemodynamic effects in patients with decompensated congestive heart failure. We …

Cyclic GMP (cGMP) made in response to atrial natriuretic peptide (ANP) or nitric oxide (NO)
is an important regulator of short-term changes in smooth muscle tone and longer-term …

Ringer bicarbonate solution containing isolated precontracted strips of bovine coronary
artery caused a rapid and pronounced, but transient, relaxant response that was …

During the last century, nitroglycerin has been the most commonly used antiischemic and
antianginal agent. Unfortunately, after continuous application, its therapeutic efficacy rapidly …

We sought to examine mechanisms underlying nitroglycerin (NTG) tolerance and" cross-
tolerance" to other nitrovasodilators. Rabbits were treated for 3 d with NTG patches (0.4 …

Organic nitrates, such as nitroglycerin (GTN), isosorbide-5-mononitrate and isosorbide
dinitrate, and pentaerithrityl tetranitrate (PETN), when given acutely, have potent vasodilator …