Research priorities for an HIV cure: international AIDS society global scientific strategy 2021
Despite the success of antiretroviral therapy (ART) for people living with HIV, lifelong
treatment is required and there is no cure. HIV can integrate in the host genome and persist …
treatment is required and there is no cure. HIV can integrate in the host genome and persist …
Immunometabolism and HIV-1 pathogenesis: food for thought
A Saez-Cirion, I Sereti - Nature reviews immunology, 2021 - nature.com
Antiretroviral therapies efficiently block HIV-1 replication but need to be maintained for life.
Moreover, chronic inflammation is a hallmark of HIV-1 infection that persists despite …
Moreover, chronic inflammation is a hallmark of HIV-1 infection that persists despite …
Parallel analysis of transcription, integration, and sequence of single HIV-1 proviruses
HIV-1-infected cells that persist despite antiretroviral therapy (ART) are frequently
considered" transcriptionally silent," but active viral gene expression may occur in some …
considered" transcriptionally silent," but active viral gene expression may occur in some …
Distinct viral reservoirs in individuals with spontaneous control of HIV-1
Sustained, drug-free control of HIV-1 replication is naturally achieved in less than 0.5% of
infected individuals (here termed 'elite controllers'), despite the presence of a replication …
infected individuals (here termed 'elite controllers'), despite the presence of a replication …
Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy
Chromosomal integration of genome-intact HIV-1 sequences into the host genome creates a
reservoir of virally infected cells that persists throughout life, necessitating indefinite …
reservoir of virally infected cells that persists throughout life, necessitating indefinite …
Lymph node dendritic cells harbor inducible replication-competent HIV despite years of suppressive ART
R Banga, FA Procopio, E Lana, GT Gladkov, I Roseto… - Cell host & …, 2023 - cell.com
Although gut and lymph node (LN) memory CD4 T cells represent major HIV and simian
immunodeficiency virus (SIV) tissue reservoirs, the study of the role of dendritic cells (DCs) …
immunodeficiency virus (SIV) tissue reservoirs, the study of the role of dendritic cells (DCs) …
Viral and host mediators of non-suppressible HIV-1 viremia
Abstract Non-suppressible HIV-1 viremia (NSV) is defined as persistent low-level viremia on
antiretroviral therapy (ART) without evidence of ART non-adherence or significant drug …
antiretroviral therapy (ART) without evidence of ART non-adherence or significant drug …
Profound phenotypic and epigenetic heterogeneity of the HIV-1-infected CD4+ T cell reservoir
Understanding the complexity of the long-lived HIV reservoir during antiretroviral therapy
(ART) remains a considerable impediment in research towards a cure for HIV. To address …
(ART) remains a considerable impediment in research towards a cure for HIV. To address …
Why and where an HIV cure is needed and how it might be achieved
Despite considerable global investment, only 60% of people who live with HIV currently
receive antiretroviral therapy. The sustainability of current programmes remains unknown …
receive antiretroviral therapy. The sustainability of current programmes remains unknown …
Single-cell epigenetic, transcriptional, and protein profiling of latent and active HIV-1 reservoir revealed that IKZF3 promotes HIV-1 persistence
Understanding how HIV-1-infected cells proliferate and persist is key to HIV-1 eradication,
but the heterogeneity and rarity of HIV-1-infected cells hamper mechanistic interrogations …
but the heterogeneity and rarity of HIV-1-infected cells hamper mechanistic interrogations …