The fluorous effect in biomolecular applications

M Cametti, B Crousse, P Metrangolo, R Milani… - Chemical Society …, 2012 - pubs.rsc.org
From being a niche area only a few decades ago, fluorous chemistry has gained momentum
and is, nowadays, a fervent area of research. It has brought forth, in fact, numerous …

Medicinal applications of perfluoroalkylated chain-containing compounds

E Prchalová, O Štěpánek, S Smrček… - Future Medicinal …, 2014 - Taylor & Francis
Compounds with polyfluorinated molecular fragments possess unique properties associated
with the presence of a large number of fluorine atoms that affect lipophilicity and …

[HTML][HTML] Untangling associations between immunoglobulin genotypes, repertoires and function

XC Dopico, M Mandolesi, GBK Hedestam - Immunology Letters, 2023 - Elsevier
Immunoglobulin (IG) genes, encoding B cell receptors (BCRs), are fundamental components
of the mammalian immune system, which evolved to recognize the diverse antigenic …

Fluorous iminoalditols: a new family of glycosidase inhibitors and pharmacological chaperones

G Schitter, AJ Steiner, G Pototschnig… - …, 2010 - Wiley Online Library
A collection of new reversible glycosidase inhibitors of the iminoalditol type featuring N‐
substituents containing perfluorinated regions has been prepared for evaluation of …

Fluorous modified magnetic mesoporous silica composites-incorporated fluorous solid-phase extraction for the specific enrichment of N-linked glycans with …

M Zhao, C Deng - Talanta, 2016 - Elsevier
Taking advantage of fluorine-fluorine interactions, fluorous solid-phase extraction (FSPE) is
emerging as a novel approach in proteomics research. Notably, silica gel bound with …

A fluorous phosphate protecting group with applications to carbohydrate synthesis

L Liu, NLB Pohl - Organic letters, 2011 - ACS Publications
The first fluorous protecting group for phosphate is reported. This group can be used as a
facile tag for purification and be removed under mild reducing conditions using zinc and …

Fluorous affinity-based separation techniques for the analysis of biogenic and related molecules

T Hayama, H Yoshida, M Yamaguchi… - Journal of Pharmaceutical …, 2014 - Elsevier
Perfluoroalkyl-containing compounds have a unique 'fluorous' property that refers to the
remarkably specific affinity they share. Fluorous compounds can be easily isolated from non …

Synthesis and properties of chemiluminescent acridinium ester labels with fluorous tags

A Natrajan, D Wen, D Sharpe - Organic & Biomolecular Chemistry, 2014 - pubs.rsc.org
Acridinium dimethylphenyl esters are highly sensitive chemiluminescent labels that are used
in clinical diagnostics. Light emission from these labels is triggered with alkaline peroxide in …

Synthesis and Antibody Binding of Highly Fluorinated Amphiphilic MUC1 Glycopeptide Antigens

T Platen, T Schüler, W Tremel, A Hoffmann‐Röder - 2011 - Wiley Online Library
The analysis of humoral immune responses is of great importance for basic and clinical
research. Mapping the structural requirements of epitope recognition with modified tumor …

Teflon af composite materials in membrane separation and molecular recognition in fluorous media

H Zhang - 2013 - search.proquest.com
The unique nature of fluoropolymers makes them potentially valuable in partitioning based
separations and sensing. Molecular diffusion and partitioning determine the selectivity of a …