Background Oral immunotherapy (OIT) is an emerging approach to the treatment of patients
with IgE-mediated food allergy and is in the process of transitioning to clinical practice …

Pharmacometric methods have hugely benefited from progress in analytical and computer
sciences during the past decades, and play nowadays a central role in the clinical …

Abstract Randomized Controlled Trials (RCTs) are increasingly popular in the social
sciences, not only in medicine. We argue that the lay public, and sometimes researchers, put …

Required reading in many medical and healthcare institutions, How to Read a Paper is a
clear and wide-ranging introduction to evidence-based medicine and healthcare, helping …

Background: Persistent depressive disorder is prevalent, disabling, and often difficult to treat.
The cognitive-behavioral analysis system of psychotherapy (CBASP) is the only …

The headline was irresistibly provocative:“Lonely flies, like many humans, eat more and
sleep less,” suggesting the proof of cause to a long-standing but unproven epidemiological …

Background Current methods for assessing strength of evidence prioritize the contributions
of randomized controlled trials (RCTs). The objective of this study was to characterize …

Background There is a lack of a comprehensive evaluation for pediatric clinical practice
guidelines (CPGs) published in recent years. Here, we assessed the quality of pediatric …

Therapeutic drug monitoring (TDM) of conventional cytotoxic chemotherapies is strongly
supported yet poorly implemented in daily practice in hospitals. Analytical methods for the …

Advances in genomic medicine are arising from efforts to build a national learning
healthcare system (LHS) and large-scale precision medicine studies. However, the …