Therapeutic opportunities within the DNA damage response
The DNA damage response (DDR) is essential for maintaining the genomic integrity of the
cell, and its disruption is one of the hallmarks of cancer. Classically, defects in the DDR have …
cell, and its disruption is one of the hallmarks of cancer. Classically, defects in the DDR have …
[HTML][HTML] Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition
LR Ferguson, H Chen, AR Collins, M Connell… - Seminars in cancer …, 2015 - Elsevier
Genomic instability can initiate cancer, augment progression, and influence the overall
prognosis of the affected patient. Genomic instability arises from many different pathways …
prognosis of the affected patient. Genomic instability arises from many different pathways …
A global genetic interaction network maps a wiring diagram of cellular function
INTRODUCTION Genetic interactions occur when mutations in two or more genes combine
to generate an unexpected phenotype. An extreme negative or synthetic lethal genetic …
to generate an unexpected phenotype. An extreme negative or synthetic lethal genetic …
[HTML][HTML] Curcumin: the spicy modulator of breast carcinogenesis
U Banik, S Parasuraman, AK Adhikary… - Journal of Experimental & …, 2017 - Springer
Worldwide breast cancer is the most common cancer in women. For many years clinicians
and the researchers are examining and exploring various therapeutic modalities for breast …
and the researchers are examining and exploring various therapeutic modalities for breast …
Base excision repair and its implications to cancer therapy
GJ Grundy, JL Parsons - Essays in biochemistry, 2020 - portlandpress.com
Base excision repair (BER) has evolved to preserve the integrity of DNA following cellular
oxidative stress and in response to exogenous insults. The pathway is a coordinated …
oxidative stress and in response to exogenous insults. The pathway is a coordinated …
Targeting DNA repair pathways for cancer treatment: what's new?
Disruptions in DNA repair pathways predispose cells to accumulating DNA damage. A
growing body of evidence indicates that tumors accumulate progressively more mutations in …
growing body of evidence indicates that tumors accumulate progressively more mutations in …
Exploiting synthetic lethality to target BRCA1/2-deficient tumors: where we stand
PS Patel, A Algouneh, R Hakem - Oncogene, 2021 - nature.com
The principle of synthetic lethality, which refers to the loss of viability resulting from the
disruption of two genes, which, individually, do not cause lethality, has become an attractive …
disruption of two genes, which, individually, do not cause lethality, has become an attractive …
[HTML][HTML] A network of conserved synthetic lethal interactions for exploration of precision cancer therapy
An emerging therapeutic strategy for cancer is to induce selective lethality in a tumor by
exploiting interactions between its driving mutations and specific drug targets. Here we use …
exploiting interactions between its driving mutations and specific drug targets. Here we use …
[HTML][HTML] Base excision repair: mechanisms and impact in biology, disease, and medicine
Base excision repair (BER) corrects forms of oxidative, deamination, alkylation, and abasic
single-base damage that appear to have minimal effects on the helix. Since its discovery in …
single-base damage that appear to have minimal effects on the helix. Since its discovery in …
[HTML][HTML] Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability
SE Tsutakawa, MJ Thompson, AS Arvai, AJ Neil… - Nature …, 2017 - nature.com
DNA replication and repair enzyme Flap Endonuclease 1 (FEN1) is vital for genome
integrity, and FEN1 mutations arise in multiple cancers. FEN1 precisely cleaves single …
integrity, and FEN1 mutations arise in multiple cancers. FEN1 precisely cleaves single …