Nanodiscs in membrane biochemistry and biophysics
IG Denisov, SG Sligar - Chemical reviews, 2017 - ACS Publications
Membrane proteins play a most important part in metabolism, signaling, cell motility,
transport, development, and many other biochemical and biophysical processes which …
transport, development, and many other biochemical and biophysical processes which …
Lipid nanodiscs for high-resolution NMR studies of membrane proteins
Membrane proteins (MPs) play essential roles in numerous cellular processes. Because
around 70% of the currently marketed drugs target MPs, a detailed understanding of their …
around 70% of the currently marketed drugs target MPs, a detailed understanding of their …
Perturbations of native membrane protein structure in alkyl phosphocholine detergents: a critical assessment of NMR and biophysical studies
Membrane proteins perform a host of vital cellular functions. Deciphering the molecular
mechanisms whereby they fulfill these functions requires detailed biophysical and structural …
mechanisms whereby they fulfill these functions requires detailed biophysical and structural …
[HTML][HTML] Using a SMALP platform to determine a sub-nm single particle cryo-EM membrane protein structure
The field of membrane protein structural biology has been revolutionized over the last few
years with a number of high profile structures being solved using cryo-EM including Piezo …
years with a number of high profile structures being solved using cryo-EM including Piezo …
Solution structure of discoidal high-density lipoprotein particles with a shortened apolipoprotein AI
S Bibow, Y Polyhach, C Eichmann, CN Chi… - Nature structural & …, 2017 - nature.com
High-density lipoprotein (HDL) particles are cholesterol and lipid transport containers.
Mature HDL particles destined for the liver develop through the formation of intermediate …
Mature HDL particles destined for the liver develop through the formation of intermediate …
Negative allosteric modulation of the glucagon receptor by RAMP2
Receptor activity-modifying proteins (RAMPs) modulate the activity of many Family B
GPCRs. We show that RAMP2 directly interacts with the glucagon receptor (GCGR), a …
GPCRs. We show that RAMP2 directly interacts with the glucagon receptor (GCGR), a …
A Peptidomimetic Antibiotic Interacts with the Periplasmic Domain of LptD from Pseudomonas aeruginosa
G Andolina, LC Bencze, K Zerbe, M Müller… - ACS chemical …, 2018 - ACS Publications
The outer membrane (OM) in Gram-negative bacteria is an asymmetric bilayer with mostly
lipopolysaccharide (LPS) molecules in the outer leaflet. During OM biogenesis, new LPS …
lipopolysaccharide (LPS) molecules in the outer leaflet. During OM biogenesis, new LPS …
DNA-corralled nanodiscs for the structural and functional characterization of membrane proteins and viral entry
Here we present a modular method for manufacturing large-sized nanodiscs using DNA-
origami barrels as scaffolding corrals. Large-sized nanodiscs can be produced by first …
origami barrels as scaffolding corrals. Large-sized nanodiscs can be produced by first …
Outer membrane protein folding from an energy landscape perspective
The cell envelope is essential for the survival of Gram-negative bacteria. This specialised
membrane is densely packed with outer membrane proteins (OMPs), which perform a …
membrane is densely packed with outer membrane proteins (OMPs), which perform a …
Vinyl ether maleic acid polymers: tunable polymers for self-assembled lipid nanodiscs and environments for membrane proteins
Native lipid bilayer mimetics, including those that use amphiphilic polymers, are important
for the effective study of membrane-bound peptides and proteins. Copolymers of vinyl ether …
for the effective study of membrane-bound peptides and proteins. Copolymers of vinyl ether …