Natural killer T (NKT) cells are a subset of CD1d-restricted T cells at the interface between
the innate and adaptive immune system. NKT cells can be subdivided into functional …

▪ Abstract Natural killer T (NKT) cells constitute a conserved T cell sublineage with unique
properties, including reactivity for a synthetic glycolipid presented by CD1d, expression of an …

Chronic liver injury characteristically results in hepatic inflammation, which represents a
prerequisite for organ fibrosis. Although NKT cells are abundantly present in liver and …

Liver natural killer and natural killer T cells not only play a critical role in anti–viral and anti–
tumor defenses but also contribute to the pathogenesis of chronic liver diseases. Hepatic …

Natural killer T (NKT) cells recognize glycolipid antigens presented by the MHC class I–
related glycoprotein CD1d. The in vivo dynamics of the NKT cell population in response to …

Purpose: Human Vα24 natural killer T (NKT) cells bearing an invariant Vα24JαQ antigen
receptor, the counterpart of murine Vα14 NKT cells, are activated by a specific ligand, α …

To optimize vaccination strategies, it is important to use protocols that can'jump-start'immune
responses by harnessing cells of the innate immune system to assist the expansion of …

Cells of the innate immune system interact with pathogens via conserved pattern-recognition
receptors, whereas cells of the adaptive immune system recognize pathogens through …

Autoimmune responses are normally kept in check by immune-tolerance mechanisms,
which include regulatory T cells. In recent years, research has focused on the role of a …

Purpose: Human Vα24 natural killer T (Vα24 NKT) cells bearing an invariant Vα24JαQ
antigen receptor are activated by a glicolipid ligand α-galactosylceramide (αGalCer; …