Thrombosis with associated inflammation (thromboinflammation) occurs commonly in a
broad range of human disorders. It is well recognized clinically in the context of superficial …

Discovered in the 1990s, protease activated receptors 1 (PARs) are membrane-spanning
cell surface proteins that belong to the G protein coupled receptor (GPCR) family. A defining …

Proteinase-activated receptors (PARs) are a subfamily of G protein-coupled receptors
(GPCRs) with four members, PAR 1, PAR 2, PAR 3 and PAR 4, playing critical functions in …

Objectives: This study sought to determine the incidence of aspirin nonresponsiveness in
addition to clopidogrel nonresponsiveness and whether this association identifies patients at …

Platelet hyperactivity associated with hyperlipidemia may contribute to development of a
prothrombotic state. We previously showed that oxidized low-density lipoprotein (oxLDL) …

Upon injury to a vessel wall the exposure of subendothelial collagen results in the activation
of platelets. Platelet activation culminates in shape change, aggregation, release of granule …

Microglia are the primary resident immune cells of the central nervous system (CNS). They
are the first line of defense of the brain's innate immune response against infection, injury …

The importance of the second messengers calcium (Ca2+) and diacylglycerol (DAG) in
platelet signal transduction was established more than 30 years ago. Whereas protein …

The mitogen‐activated protein (MAP) kinases ERK2, p38 and JNK1 are present in platelets
and are activated by various stimuli, such as thrombin, collagen, von Willebrand factor …

Thrombin is the central protease in the coagulation cascade and one of the most extensively
studied of all enzymes. In addition to its recognised role in the coagulation cascade and …