Cancer multidrug-resistance reversal by ABCB1 inhibition: A recent update

K Engle, G Kumar - European journal of medicinal chemistry, 2022 - Elsevier
Chemotherapy is one of the most common treatments for cancer that uses one or more anti-
cancer drugs as a part of the standardized chemotherapy regimen. Cytotoxic chemicals …

Drug repurposing for cancer therapy

Y Xia, M Sun, H Huang, WL Jin - Signal Transduction and Targeted …, 2024 - nature.com
Cancer, a complex and multifactorial disease, presents a significant challenge to global
health. Despite significant advances in surgical, radiotherapeutic and immunological …

Inhalation delivery of repurposed drugs for lung cancer: approaches, benefits and challenges

P Kumbhar, A Manjappa, R Shah, NK Jha… - Journal of Controlled …, 2022 - Elsevier
Lung cancer (LC) is one of the leading causes of mortality accounting for almost 25% of
cancer deaths throughout the world. The shortfall of affordable and effective first-line …

Hydrolysis, Ligand Exchange, and Redox Properties of Vanadium Compounds: Implications of Solution Transformation on Biological, Therapeutic, and Environmental …

R Dinda, E Garribba, D Sanna, DC Crans… - Chemical …, 2025 - ACS Publications
Vanadium is a transition metal with important industrial, technological, biological, and
biomedical applications widespread in the environment and in living beings. The different …

Drug repurposing: an effective tool in modern drug discovery

VS Kulkarni, V Alagarsamy, VR Solomon… - Russian Journal of …, 2023 - Springer
Drug repurposing is using an existing drug for a new treatment that was not indicated before.
It has received immense attention during the COVID-19 pandemic emergency. Drug …

Krebs cycle: activators, inhibitors and their roles in the modulation of carcinogenesis

A Gasmi, M Peana, M Arshad, M Butnariu… - Archives of …, 2021 - Springer
A fundamental metabolic feature of cancerous tissues is high glucose consumption. The rate
of glucose consumption in a cancer cell can be 10–15 times higher than in normal cells …

[HTML][HTML] Repurposing non-oncology small-molecule drugs to improve cancer therapy: Current situation and future directions

L Fu, W Jin, J Zhang, L Zhu, J Lu, Y Zhen… - … Pharmaceutica Sinica B, 2022 - Elsevier
Drug repurposing or repositioning has been well-known to refer to the therapeutic
applications of a drug for another indication other than it was originally approved for …

High-dimensional role of AI and machine learning in cancer research

E Capobianco - British journal of cancer, 2022 - nature.com
Abstract The role of Artificial Intelligence and Machine Learning in cancer research offers
several advantages, primarily scaling up the information processing and increasing the …

Molecular modeling strategies of cancer multidrug resistance

G Yalcin-Ozkat - Drug Resistance Updates, 2021 - Elsevier
Cancer remains a leading cause of morbidity and mortality worldwide. Hence, the increase
in cancer cases observed in the elderly population, as well as in children and adolescents …

[HTML][HTML] Repurposing antifungal drugs for cancer therapy

N Weng, Z Zhang, Y Tan, X Zhang, X Wei… - Journal of Advanced …, 2023 - Elsevier
Background Repurposing antifungal drugs in cancer therapy has attracted unprecedented
attention in both preclinical and clinical research due to specific advantages, such as safety …