Intracellular and extracellular interactions with proteins enables the functional and
mechanistic diversity of lipids. Fatty acid-binding proteins (FABPs) were originally described …

Fatty acid trafficking in cells affects many aspects of cellular function3). Fatty acids act both
as an energy source and as signals for metabolic regulations including gene expression …

Over the past decade, evidences of an integration of metabolic and inflammatory pathways,
referred to as metaflammation in several aspects of metabolic syndrome, have been …

Metabolic and immune systems are among the most fundamental requirements for survival.
Many metabolic and immune response pathways or nutrient-and pathogen-sensing systems …

Lipids are vital components of many biological processes and crucial in the pathogenesis of
numerous common diseases, but the specific mechanisms coupling intracellular lipids to …

The proper functioning of the pathways that are involved in the sensing and management of
nutrients is central to metabolic homeostasis and is therefore among the most fundamental …

Fatty acid-binding proteins (FABPs) are members of the intracellular lipid-binding protein
(iLBP) family and are involved in reversibly binding intracellular hydrophobic ligands and …

Dysregulation of lipid metabolism in individual tissues leads to systemic disruption of insulin
action and glucose metabolism. Utilizing quantitative lipidomic analyses and mice deficient …

The liberation of energy stores from adipocytes is critical to support survival in times of
energy deficit; however, uncontrolled or chronic lipolysis associated with insulin resistance …

The incidence of obesity has increased dramatically during recent decades. Obesity will
cause a decline in life expectancy for the first time in recent history due to numerous co …