Microtubules are dynamic polymers of αβ-tubulin that are essential for intracellular
organization, organelle trafficking and chromosome segregation. Microtubule growth and …

Kinesins are a diverse superfamily of microtubule-based motors that perform fundamental
roles in intracellular transport, cytoskeletal dynamics and cell division. These motors share a …

Understanding the pathogenic mechanisms of disease mutations is critical to advancing
treatments. ALS-associated mutations in the gene encoding the microtubule motor KIF5A …

Kinesin-1 is responsible for microtubule-based transport of numerous cellular cargoes.
Here, we explored the regulation of kinesin-1 by MAP7 proteins. We found that all four …

Highlights•Regulation of non-centrosomal microtubule organization in neurons.•Role of
resilient acetylated microtubules in mechanosensation.•Patterning microtubule tracks to …

The dynamic instability of microtubules plays a key role in controlling their organization and
function, but the cellular mechanisms regulating this process are poorly understood. Here …

Centrioles are microtubule-based organelles required for the formation of centrosomes and
cilia. Centriolar microtubules, unlike their cytosolic counterparts, are stable and grow very …

Microtubules are dynamic cytoskeletal polymers, and their organization and stability are
tightly regulated by numerous cellular factors. While regulatory proteins controlling the …

Heterozygous, missense mutations in both α-and β-tubulin genes have been linked to an
array of neurodevelopment disorders, commonly referred to as “tubulinopathies.” To date …

The Kinesin superfamily proteins (KIFs) are major molecular motors that transport diverse
set of cargoes along microtubules to both the axon and dendrite of a neuron. Much of our …