Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
Ligand-gated ion channels: new insights into neurological disorders and ligand recognition
1. INTRODUCTION Ligand-gated ion channels (LGICs) mediate intercellular communication
by converting the binding of a neurotransmitter that is released from the presynaptic terminal …
by converting the binding of a neurotransmitter that is released from the presynaptic terminal …
Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM
Glutamate-gated AMPA receptors mediate the fast component of excitatory signal
transduction at chemical synapses throughout all regions of the mammalian brain. AMPA …
transduction at chemical synapses throughout all regions of the mammalian brain. AMPA …
Functional insights from glutamate receptor ion channel structures
X-ray crystal structures for the soluble amino-terminal and ligand-binding domains of
glutamate receptor ion channels, combined with a 3.6-Å-resolution structure of the full-length …
glutamate receptor ion channels, combined with a 3.6-Å-resolution structure of the full-length …
Origanum syriacum Phytochemistry and Pharmacological Properties: A Comprehensive Review
Herbal medicine has been gaining special interest as an alternative choice of treatment for
several diseases, being generally accessible, cost-effective and safe, with fewer side-effects …
several diseases, being generally accessible, cost-effective and safe, with fewer side-effects …
Emerging structural insights into the function of ionotropic glutamate receptors
E Karakas, MC Regan, H Furukawa - Trends in biochemical sciences, 2015 - cell.com
Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate
excitatory neurotransmission crucial for brain development and function, including learning …
excitatory neurotransmission crucial for brain development and function, including learning …
Biology of AMPA receptor interacting proteins-From biogenesis to synaptic plasticity
PM Matthews, A Pinggera, D Kampjut, IH Greger - Neuropharmacology, 2021 - Elsevier
AMPA-type glutamate receptors mediate the majority of excitatory synaptic transmission in
the central nervous system. Their signaling properties and abundance at synapses are both …
the central nervous system. Their signaling properties and abundance at synapses are both …
Emerging models of glutamate receptor ion channel structure and function
ML Mayer - Structure, 2011 - cell.com
Excitatory synaptic transmission in the brain is mediated by ligand-gated ion channels
(iGluRs) activated by glutamate. Distinct from other neurotransmitter receptors, the …
(iGluRs) activated by glutamate. Distinct from other neurotransmitter receptors, the …
The role of GluA1 in central nervous system disorders
J Zhang, JM Abdullah - Reviews in the Neurosciences, 2013 - degruyter.com
In the brain, the four subunits of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
(AMPA) receptor, glutamate A 1 (GluA 1), GluA 2, GluA 3, and GluA 4 form functionally …
(AMPA) receptor, glutamate A 1 (GluA 1), GluA 2, GluA 3, and GluA 4 form functionally …
Structure, dynamics, and allosteric potential of ionotropic glutamate receptor N-terminal domains
Ionotropic glutamate receptors (iGluRs) are tetrameric cation channels that mediate synaptic
transmission and plasticity. They have a unique modular architecture with four domains: the …
transmission and plasticity. They have a unique modular architecture with four domains: the …