Simple Summary L-asparaginase (L-ASNase) therapy is key for achieving the very high cure
rate of pediatric acute lymphoblastic leukemia (ALL), yet its use is mostly confined to this …

Acute lymphoblastic leukemia (ALL) is a rare hematologic malignancy resulting in the
production of abnormal lymphoid precursor cells. Occurring in B-cell and T-cell subtypes …

Purpose Early intensification with methotrexate (MTX) is a key component of acute
lymphoblastic leukemia (ALL) therapy. Two different approaches to MTX intensification exist …

Osteonecrosis is a significant toxicity of acute lymphoblastic leukemia (ALL) therapy. In
retrospective analyses, superior event-free survival was noted among affected adolescents …

Antibodies against polyethylene glycol (PEG) in healthy subjects raise concerns about the
efficacy of pegylated drugs. We evaluated the prevalence of antibodies against PEG among …

Arginine is a semi‐essential amino acid that plays a key role in cell survival and proliferation
in normal and malignant cells. BCT‐100, a pegylated (PEG) recombinant human arginase …

Purpose The benefits of asparaginase (ASNASE) in the treatment of ALL and NHL are
indisputable and new ASNASE preparations are under clinical development to overcome …

Asparagine levels in cerebrospinal fluid and serum asparaginase activity were monitored in
children with acute lymphoblastic leukemia treated with pegylated-asparaginase. The drug …

Asparaginase is essential in childhood acute lymphoblastic leukaemia (ALL) treatment,
however hypersensitivity reactions to pegylated asparaginase (PEG‐asparaginase) …

Asparaginase (ASNase) therapy has been a mainstay of acute lymphoblastic leukemia
(ALL) protocols for decades and shows promise in the treatment of a variety of other …