The aim of this article is to describe the current and potential clinical translation of
pharmacological inhibitors of poly (ADP-ribose) polymerase (PARP) for the therapy of …

Ursolic acid (UA) is a natural pentacyclic triterpenoid compound, which is enriched with
many herbs and plants, such as apple, cranberry and olive. UA performs multiple biological …

Purpose: In the eye, chronic hypoxia/reoxygenation (H/R) contributes to the development of
a number of ocular disorders. H/R induces the production of reactive oxygen species (ROS) …

Alkylating agents comprise a major class of front-line cancer chemotherapeutic compounds,
and while these agents effectively kill tumor cells, they also damage healthy tissues …

Background Cardiovascular diseases are the leading cause of death in many countries and
myocardial ischemia-reperfusion (I/R) injury is the cause of many serious heart diseases …

Abstract Optic atrophy 1 (Opa1) is a critical factor that regulates fusion and other important
functions of mitochondria. In mitochondrion, the N-terminal mitochondrial targeting …

Background Retinal ischemia/reperfusion (I/R) injury is one of significant cause of visual
dysopia and causes inflammatory response. Dexmedetomidine is widely applied to …

Familial dysautonomia (FD) is a rare genetic neurodevelopmental and neurodegenerative
disorder. In addition to the autonomic and peripheral sensory neuropathies that challenge …

The progressive loss of structure and function of neurons leads to neurodegenerative
processes which become the causative reason for various neurodegenerative diseases …

In this study we quantified the alterations of retinal histone post-translational modifications
(PTMs) in diabetic rats using a liquid chromatography-tandem mass spectrometry (LC …