The extracellular matrix as a multitasking player in disease
Extracellular matrices (ECM s) are highly specialized and dynamic three‐dimensional (3D)
scaffolds into which cells reside in tissues. ECM is composed of a variety of fibrillar …
scaffolds into which cells reside in tissues. ECM is composed of a variety of fibrillar …
Extracellular matrix structure
Extracellular matrix (ECM) is a non-cellular three-dimensional macromolecular network
composed of collagens, proteoglycans/glycosaminoglycans, elastin, fibronectin, laminins …
composed of collagens, proteoglycans/glycosaminoglycans, elastin, fibronectin, laminins …
Proteoglycan chemical diversity drives multifunctional cell regulation and therapeutics
The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …
Glycosaminoglycans: key players in cancer cell biology and treatment
Glycosaminoglycans are natural heteropolysaccharides that are present in every
mammalian tissue. They are composed of repeating disaccharide units that consist of either …
mammalian tissue. They are composed of repeating disaccharide units that consist of either …
Proteoglycans remodeling in cancer: Underlying molecular mechanisms
AD Theocharis, NK Karamanos - Matrix Biology, 2019 - Elsevier
Extracellular matrix is a highly dynamic macromolecular network. Proteoglycans are major
components of extracellular matrix playing key roles in its structural organization and cell …
components of extracellular matrix playing key roles in its structural organization and cell …
Proteoglycans in health and disease: novel roles for proteoglycans in malignancy and their pharmacological targeting
The expression of proteoglycans (PGs), essential macromolecules of the tumor
microenvironment, is markedly altered during malignant transformation and tumor …
microenvironment, is markedly altered during malignant transformation and tumor …
[HTML][HTML] The extracellular matrix of hematopoietic stem cell niches
C Lee-Thedieck, P Schertl, G Klein - Advanced Drug Delivery Reviews, 2022 - Elsevier
Hematopoietic stem cells (HSCs) are the life-long source of all types of blood cells. Their
function is controlled by their direct microenvironment, the HSC niche in the bone marrow …
function is controlled by their direct microenvironment, the HSC niche in the bone marrow …
[HTML][HTML] Cross-talk between estradiol receptor and EGFR/IGF-IR signaling pathways in estrogen-responsive breast cancers: focus on the role and impact of …
In hormone-dependent breast cancer, estrogen receptors are the principal signaling
molecules that regulate several cell functions either by the genomic pathway acting directly …
molecules that regulate several cell functions either by the genomic pathway acting directly …
[HTML][HTML] Extracellular matrix components and mechanosensing pathways in health and disease
A Berdiaki, M Neagu, P Tzanakakis, I Spyridaki… - Biomolecules, 2024 - mdpi.com
Glycosaminoglycans (GAGs) and proteoglycans (PGs) are essential components of the
extracellular matrix (ECM) with pivotal roles in cellular mechanosensing pathways. GAGs …
extracellular matrix (ECM) with pivotal roles in cellular mechanosensing pathways. GAGs …
Insights into the key roles of proteoglycans in breast cancer biology and translational medicine
Proteoglycans control numerous normal and pathological processes, among which are
morphogenesis, tissue repair, inflammation, vascularization and cancer metastasis. During …
morphogenesis, tissue repair, inflammation, vascularization and cancer metastasis. During …