Many proteins and protein segments cannot attain a single stable three-dimensional
structure under physiological conditions; instead, they adopt multiple interconverting …

Tardigrades are ubiquitous meiofauna that are especially renowned for their exceptional
extremotolerance to various adverse environments, including pressure, temperature, and …

The massive worldwide spread of the SARS-CoV-2 virus is fueling the COVID-19 pandemic.
Since the first whole-genome sequence was published in January 2020, a growing …

The power of structural information for informing biological mechanisms is clear for stable
folded macromolecules, but similar structure–function insight is more difficult to obtain for …

Tardigrada is an ecdysozoan lineage famed for its resilience. Tardigrades can tolerate high
doses of radiation, low-oxygen environments, desiccation, and both high and low …

Evolutionary preservation of protein structure had a major influence on the field of molecular
evolution: changes in individual amino acids that did not disrupt protein folding would either …

Abstract The Major Histocompatibility Complex (MHC) binds to the derived peptides from
pathogens to present them to killer T cells on the cell surface. Developing computational …

Sequence analysis is the primary and simplest approach to discover structural, functional
and evolutionary details of related proteins. All the alignment based approaches of …

Low complexity regions are fragments of protein sequences composed of only a few types of
amino acids. These regions frequently occur in proteins and can play an important role in …

Molecular chaperones maintain proteostasis by ensuring the proper folding of polypeptides.
Loss of proteostasis has been linked to numerous neurodegenerative disorders including …