PTZ kindling model for epileptogenesis, refractory epilepsy, and associated comorbidities: relevance and reliability
Pentylenetetrazole (PTZ)-induced seizure is one of the gold standard mouse models for
rapid evaluation of novel anticonvulsants. Synchronically, PTZ induced kindling in mice is …
rapid evaluation of novel anticonvulsants. Synchronically, PTZ induced kindling in mice is …
[HTML][HTML] Cannabidiol modulates excitatory-inhibitory ratio to counter hippocampal hyperactivity
EC Rosenberg, S Chamberland, M Bazelot, ER Nebet… - Neuron, 2023 - cell.com
Summary Cannabidiol (CBD), a non-euphoric component of cannabis, reduces seizures in
multiple forms of pediatric epilepsies, but the mechanism (s) of anti-seizure action remain …
multiple forms of pediatric epilepsies, but the mechanism (s) of anti-seizure action remain …
On-demand cell-autonomous gene therapy for brain circuit disorders
Several neurodevelopmental and neuropsychiatric disorders are characterized by
intermittent episodes of pathological activity. Although genetic therapies offer the ability to …
intermittent episodes of pathological activity. Although genetic therapies offer the ability to …
Pentylenetetrazole: A review
ÁB Monteiro, AF Alves, ACR Portela, HFO Pires… - Neurochemistry …, 2024 - Elsevier
Pentylenetetrazole (PTZ), a tetrazole derivative, is commonly used as a chemical agent to
induce neurological disorders and replicate the characteristics of human epileptic seizures …
induce neurological disorders and replicate the characteristics of human epileptic seizures …
[HTML][HTML] Structure and topography of the synaptic V-ATPase–synaptophysin complex
Synaptic vesicles are organelles with a precisely defined protein and lipid composition,, yet
the molecular mechanisms for the biogenesis of synaptic vesicles are mainly unknown. Here …
the molecular mechanisms for the biogenesis of synaptic vesicles are mainly unknown. Here …
[HTML][HTML] Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models
M Das, W Mao, Y Voskobiynyk, D Necula, I Lew… - Neurobiology of …, 2023 - Elsevier
The R47H variant of triggering receptor expressed on myeloid cells 2 (TREM2) increases
the risk of Alzheimer's disease (AD). To investigate potential mechanisms, we analyzed …
the risk of Alzheimer's disease (AD). To investigate potential mechanisms, we analyzed …
[HTML][HTML] Direct activation of KCC2 arrests benzodiazepine refractory status epilepticus and limits the subsequent neuronal injury in mice
Summary Hyperpolarizing GABA AR currents, the unitary events that underlie synaptic
inhibition, are dependent upon efficient Cl− extrusion, a process that is facilitated by the …
inhibition, are dependent upon efficient Cl− extrusion, a process that is facilitated by the …
Cortical hyperexcitability in mouse models and patients with amyotrophic lateral sclerosis is linked to noradrenaline deficiency
J Scekic-Zahirovic, C Benetton, A Brunet… - Science Translational …, 2024 - science.org
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease,
characterized by the death of upper (UMN) and lower motor neurons (LMN) in the motor …
characterized by the death of upper (UMN) and lower motor neurons (LMN) in the motor …
[HTML][HTML] Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer's disease
Dysfunctions of network activity and functional connectivity (FC) represent early events in
Alzheimer's disease (AD), but the underlying mechanisms remain unclear. Astrocytes …
Alzheimer's disease (AD), but the underlying mechanisms remain unclear. Astrocytes …
The cell-permeable mitochondrial calcium uniporter inhibitor Ru265 preserves cortical neuron respiration after lethal oxygen glucose deprivation and reduces hypoxic …
RJ Novorolsky, M Nichols, JS Kim… - Journal of Cerebral …, 2020 - journals.sagepub.com
The mitochondrial calcium (Ca2+) uniporter (MCU) mediates high-capacity mitochondrial
Ca2+ uptake implicated in ischemic/reperfusion cell death. We have recently shown that …
Ca2+ uptake implicated in ischemic/reperfusion cell death. We have recently shown that …