Cell death mechanisms in stroke and novel molecular and cellular treatment options

E Sekerdag, I Solaroglu… - Current …, 2018 - ingentaconnect.com
As a result of ischemia or hemorrhage, blood supply to neurons is disrupted which
subsequently promotes a cascade of pathophysiological responses resulting in cell loss …

Nitric oxide/nitric oxide synthase system in the pathogenesis of neurodegenerative disorders—an overview

OM Iova, GE Marin, I Lazar, I Stanescu, G Dogaru… - Antioxidants, 2023 - mdpi.com
Nitric oxide, a ubiquitous molecule found throughout the natural world, is a key molecule
implicated in many central and benefic molecular pathways and has a well-established role …

Powered Air Purifying Respirator (PAPR) restores the N95 face mask induced cerebral hemodynamic alterations among Healthcare Workers during COVID-19 …

C Bharatendu, JJY Ong, Y Goh, BYQ Tan… - Journal of the …, 2020 - Elsevier
Background and aim COVID-19 pandemic has resulted in an unprecedented increased
usage of Personal protective equipment (PPE) by healthcare-workers. PPE usage causes …

Circular RNA expression profiles alter significantly in mouse brain after transient focal ischemia

SL Mehta, G Pandi, R Vemuganti - Stroke, 2017 - Am Heart Assoc
Background and Purpose—Circular RNAs (circRNAs) are a novel class of noncoding RNAs
formed from many protein-coding genes by backsplicing. Although their physiological …

Emerging Treatment Strategies for Cerebral Ischemia–Reperfusion Injury

M Li, H Tang, Z Li, W Tang - Neuroscience, 2022 - Elsevier
Cerebral ischemia–reperfusion injury (CI/RI) injury is a common feature of ischemic stroke
which occurs when the blood supply is restored after a period of ischemia in the brain …

Associations between cerebrovascular risk factors and parkinson disease

BR Kummer, I Diaz, X Wu, AE Aaroe… - Annals of …, 2019 - Wiley Online Library
Objective To determine whether cerebrovascular risk factors are associated with subsequent
diagnoses of Parkinson disease, and whether these associations are similar in magnitude to …

The potential role of MicroRNA-124 in cerebral ischemia injury

X Liu, Z Feng, L Du, Y Huang, J Ge, Y Deng… - International journal of …, 2019 - mdpi.com
Cerebral ischemia injury, the leading cause of morbidity and mortality worldwide, initiates
sequential molecular and cellular pathologies that underlie ischemic encephalopathy (IE) …

The microRNA miR-7a-5p ameliorates ischemic brain damage by repressing α-synuclein

TH Kim, SL Mehta, KC Morris-Blanco, AK Chokkalla… - Science …, 2018 - science.org
Ischemic stroke, which is caused by a clot that blocks blood flow to the brain, can be
severely disabling and sometimes fatal. We previously showed that transient focal ischemia …

Cerebral small vessel disease progression increases risk of incident parkinsonism

MA Jacob, M Cai, M Bergkamp… - Annals of …, 2023 - Wiley Online Library
Objective Cerebral small vessel disease (SVD) is associated with motor impairments and
parkinsonian signs cross‐sectionally, however, there are little longitudinal data on whether …

LRRK2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia

J Kim, E Pajarillo, A Rizor, DS Son, J Lee, M Aschner… - PloS one, 2019 - journals.plos.org
Long-term exposure to elevated levels of manganese (Mn) causes manganism, a
neurodegenerative disorder with Parkinson's disease (PD)-like symptoms. Increasing …