Pathogenicity and virulence of the liver flukes Fasciola hepatica and Fasciola Gigantica that cause the zoonosis Fasciolosis

R Lalor, K Cwiklinski, NED Calvani, A Dorey, S Hamon… - Virulence, 2021 - Taylor & Francis
Fasciolosis caused by the liver flukes Fasciola hepatica and Fasciola gigantica is one of the
most important neglected parasitic diseases of humans and animals. The ability of the …

Multifunctional fructose 1, 6-bisphosphate aldolase as a therapeutic target

DB Pirovich, AA Da'dara, PJ Skelly - Frontiers in molecular …, 2021 - frontiersin.org
Fructose 1, 6-bisphosphate aldolase is a ubiquitous cytosolic enzyme that catalyzes the
fourth step of glycolysis. Aldolases are classified into three groups: Class-I, Class-IA, and …

Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform

A Rai, H Fang, B Claridge, RJ Simpson… - Journal of …, 2021 - Wiley Online Library
The extracellular vesicle (EV) surface proteome (surfaceome) acts as a fundamental
signalling gateway by bridging intra‐and extracellular signalling networks, dictates EVs' …

Vesicle-based secretion in schistosomes: Analysis of protein and microRNA (miRNA) content of exosome-like vesicles derived from Schistosoma mansoni

V Samoil, M Dagenais, V Ganapathy, J Aldridge… - Scientific reports, 2018 - nature.com
Exosomes are small vesicles of endocytic origin, which are released into the extracellular
environment and mediate a variety of physiological and pathological conditions. Here we …

Characterization of the Giardia intestinalis secretome during interaction with human intestinal epithelial cells: The impact on host cells

SY Ma'ayeh, J Liu, D Peirasmaki… - PLoS neglected …, 2017 - journals.plos.org
Background Giardia intestinalis is a non-invasive protozoan parasite that causes giardiasis
in humans, the most common form of parasite-induced diarrhea. Disease mechanisms are …

Regulation of Virulence of Entamoeba histolytica

C Marie, WA Petri Jr - Annual review of microbiology, 2014 - annualreviews.org
Entamoeba histolytica is the third-leading cause of parasitic mortality globally. E. histolytica
infection generally does not cause symptoms, but the parasite has potent pathogenic …

Moonlighting proteins at the candidal cell surface

D Satala, J Karkowska-Kuleta, A Zelazna… - Microorganisms, 2020 - mdpi.com
The cell wall in Candida albicans is not only a tight protective envelope but also a point of
contact with the human host that provides a dynamic response to the constantly changing …

Development of a Nanobody-based lateral flow assay to detect active Trypanosoma congolense infections

JE Pinto Torres, J Goossens, J Ding, Z Li, S Lu… - Scientific reports, 2018 - nature.com
Animal African trypanosomosis (AAT), a disease affecting livestock, is caused by parasites of
the Trypanosoma genus (mainly T. vivax and T. congolense). AAT is widespread in Sub …

The road less traveled? Unconventional protein secretion at parasite–host interfaces

EA Balmer, C Faso - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Protein secretion in eukaryotic cells is a well-studied process, which has been known for
decades and is dealt with by any standard cell biology textbook. However, over the past 20 …

Giardia duodenalis virulence—“to be, or not to be”

R Argüello-García, MG Ortega-Pierres - Current Tropical Medicine Reports, 2021 - Springer
Purpose of review Here, we review recent progress made on the genetic characterization of
Giardia duodenalis assemblages and their relationship with virulence. We also discuss the …