Human effector CD8+ T cells with an activated and exhausted-like phenotype control tumour growth in vivo in a humanized tumour model
Background Humanized tumour models could be particularly valuable for cancer
immunotherapy research, as they may better reflect human-specific aspects of the interfaces …
immunotherapy research, as they may better reflect human-specific aspects of the interfaces …
A multimodal cross-species comparison of pancreas development
Human pancreas development remains incompletely understood due to limited sample
access constrained by ethical and practical considerations. Here we investigate whether …
access constrained by ethical and practical considerations. Here we investigate whether …
[HTML][HTML] Computational strategies for cross-species knowledge transfer and translational biomedicine
Research organisms provide invaluable insights into human biology and diseases, serving
as essential tools for functional experiments, disease modeling, and drug testing. However …
as essential tools for functional experiments, disease modeling, and drug testing. However …
In Silico Treatment: a computational framework for animal model selection and drug assessment
S Picart-Armada, K Becker, M Kaestle, O Krenkel… - bioRxiv, 2024 - biorxiv.org
The translation of findings from animal models to human disease is a fundamental part in the
field of drug development. However, only a small proportion of promising preclinical results …
field of drug development. However, only a small proportion of promising preclinical results …
Human effector CD8+ T cells with an exhausted-like phenotype control tumor growth in vivo in a humanized tumor model
Background Humanized tumor models could be particularly valuable for cancer
immunotherapy research, as they may better reflect human-specific aspects of the interfaces …
immunotherapy research, as they may better reflect human-specific aspects of the interfaces …
[PDF][PDF] Human effector CD8+ T cells with an exhausted-like phenotype control tumor growth in vivo
Abstract 1 The functional relevance of CD8+ T cell phenotypes in human cancer is not well
established. 2 In preclinical studies, murine CD8+ T cells exhibiting an exhausted-like …
established. 2 In preclinical studies, murine CD8+ T cells exhibiting an exhausted-like …
Of Mouse Models and Humans
In a nondescript laboratory, a university researcher using mouse models to find new drugs to
treat major depressive disorder finds an interesting potential drug target. She is so sure this …
treat major depressive disorder finds an interesting potential drug target. She is so sure this …