Background The marine environment hosts a wide variety of species that have evolved to
live in harsh and challenging conditions. Marine organisms are the focus of interest due to …

Covering: 2006 to 2017 Actinomycetes have been, for decades, one of the most important
sources for the discovery of new antibiotics with an important number of drugs and analogs …

The growing resistance of microorganisms towards antibiotics has become a serious global
problem. Therapeutics with novel chemical scaffolds and/or mechanisms of action are …

The ability to produce plethora of secondary metabolites and enzymes for pharmaceutical,
agricultural and biotechnological applications make actinobacteria one of the most explored …

The use of fertilizers and chemical pesticides promotes significant improvements in crop
development, but some problems and risks associated with them limit their application. An …

[4+ 2]-Cycloadditions are increasingly being recognized in the biosynthetic pathways of
many structurally complex natural products. A relatively small collection of enzymes from …

Background Antibiotic resistance is on the rise, and new antibiotic research has slowed in
recent years, necessitating the discovery of possibly novel microbial resources capable of …

Micromonospora, one of the most important actinomycetes genera, is well-known as the
treasure trove of bioactive secondary metabolites (SMs). Herein, together with an in-depth …

The wide abundance of γ-lactones in natural products and bioactive targets calls for suitable
building blocks for their enantioselective synthesis. β, γ-Unsaturated γ-butenolides …

Organocatalysis is shown to expand the classical reactivity pattern for conjugate addition
reactions. It is demonstrated that the site selectivity can be extended from 1, 4-to 1, 6 …