Is the efficacy of oxytocin for autism diminished at higher dosages or repeated doses?: potential mechanisms and candidate solutions

H Yamasue - Peptides, 2023 - Elsevier
No approved pharmacological intervention currently exists to address the core symptoms of
autism spectrum disorder, a prevalent neurodevelopmental condition. However, there is a …

[HTML][HTML] The use of intranasal oxytocin in the treatment of eating disorders

M Malewska-Kasprzak, K Jowik, M Tyszkiewicz-Nwafor - Neuropeptides, 2023 - Elsevier
Oxytocin (OXT) is a hypothalamic peptide that plays a number of roles in the body, being
involved in labor and lactation, as well as cognitive-emotional processes and social …

Oxytocin treatment for core symptoms in children with autism spectrum disorder: A systematic review and meta-analysis

L Hu, X Du, Z Jiang, C Song, D Liu - European Journal of Clinical …, 2023 - Springer
Purpose The purpose of this article is to examine the efficacy of oxytocin in treating core
symptoms of autism spectrum disorder (ASD) with children. Methods A systematic literature …

The dopamine hypothesis of autism spectrum disorder: A comprehensive analysis of the evidence

D Pavăl - International Review of Neurobiology, 2023 - Elsevier
Despite intensive research into the etiopathogenesis of autism spectrum disorder (ASD),
limited progress has been achieved so far. Among the plethora of models seeking to clarify …

A clustering approach identifies an Autism Spectrum Disorder subtype more responsive to chronic oxytocin treatment

W Zhao, J Le, Q Liu, S Zhu, C Lan, Q Zhang… - Translational …, 2024 - nature.com
Over the last decade, a number of clinical trials have reported effects of chronic treatment
with intranasal oxytocin on autistic symptoms but with inconsistent findings. Autism is a …

Cannabinoid treatment for the symptoms of autism spectrum disorder

A Aran, D Cayam Rand - Expert Opinion on Emerging Drugs, 2024 - Taylor & Francis
Introduction Autism spectrum disorder (ASD) is a neurodevelopmental disorder affecting
approximately 3% of school-age children. The core symptoms are deficits in social …

Chronic oxytocin improves neural decoupling at rest in children with autism: an exploratory RCT

K Alaerts, M Moerkerke, N Daniels… - Journal of Child …, 2024 - Wiley Online Library
Background Shifts in peak frequencies of oscillatory neural rhythms are put forward as a
principal mechanism by which cross‐frequency coupling/decoupling is implemented in the …

[HTML][HTML] Intranasal oxytocin in pediatric populations: Exploring the potential for reducing irritability and modulating neural responses: A mini review

K Sorenson, E Kendall, H Grell, M Kang… - Journal of psychiatry …, 2023 - ncbi.nlm.nih.gov
Endogenous neuropeptide Oxytocin (OXT) plays a crucial role in modulating pro-social
behavior and the neural response to social/emotional stimuli. Intranasal administration is the …

Highly specific detection of oxytocin in saliva

M Rana, N Yildirim, NE Ward, SP Vega… - International Journal of …, 2023 - mdpi.com
Oxytocin is a peptide neurophysin hormone made up of nine amino acids and is used in
induction of one in four births worldwide (more than 13 percent in the United States). Herein …

Acute, chronic and conditioned effects of intranasal oxytocin in the mu-opioid receptor knockout mouse model of autism: Social context matters

F Pantouli, CN Pujol, C Derieux, M Fonteneau… - …, 2024 - nature.com
Abstract Autism Spectrum Disorders (ASD) are neurodevelopmental disorders whose
diagnosis relies on deficient social interaction and communication together with repetitive …