The human major histocompatibility complex is a family of genes that encodes HLAs, which
have a crucial role in defence against foreign pathogens and immune surveillance of …

The ways we measure whether a patient is sensitized to HLA antigens and to what extent
sensitization affects access to transplantation have changed remarkably during the past …

The clinical importance of preexisting HLA antibodies at the time of transplantation,
identified by contemporary techniques, is not well understood. We conducted an …

The presence of donor-specific HLA antibodies before or after transplantation may have
different implications based on the antibody strength. Yet, current approaches do not provide …

Alloantibodies directed against HLA antigens, are a barrier to long-term solid organ allograft
survival. The clinical impact of preformed, donor-directed HLA alloantibodies range from …

Crossmatching of potential renal donors against potential renal transplant recipients has
been performed for over 40 years and is a mandatory component of the transplant work‐up …

Background It is widely accepted that HLA donor-specific antibodies (DSA) are associated
with antibody-mediated rejection and graft loss. However, in many transplant programs …

The flow cytometric crossmatch (FCXM) assay, which detects the presence of donor specific
HLA antibodies in patient sera, is a cornerstone of HLA compatibility testing. Since relatively …

Solid phase immunoassays (SPI) are now routinely used to detect HLA antibodies.
However, the flow cytometric crossmatch (FCXM) remains the established method for …

Background. We previously reported that in patients possessing human leukocyte antigen
(HLA)-DQ-directed antibodies, the target molecule may include the patient's own DQβ chain …