A Step-by-Step Guide for the Novel Radiometal Production for Medical Applications: Case Studies with 68Ga, 44Sc, 177Lu and 161Tb

Z Talip, C Favaretto, S Geistlich, NP Meulen - Molecules, 2020 - mdpi.com
The production of novel radionuclides is the first step towards the development of new
effective radiopharmaceuticals, and the quality thereof directly affects the preclinical and …

Production of radiometals in liquid targets

SJC Do Carmo, PJH Scott, F Alves - EJNMMI Radiopharmacy and …, 2020 - Springer
Over the last several years, the use of radiometals has gained increasing relevance in
supporting the continuous development of new, complementary and more specific biological …

Cyclotron-based production of 68Ga, [68Ga]GaCl3, and [68Ga]Ga-PSMA-11 from a liquid target

ME Rodnick, C Sollert, D Stark, M Clark… - EJNMMI …, 2020 - Springer
Purpose To optimize the direct production of 68 Ga on a cyclotron, via the 68 Zn (p, n) 68 Ga
reaction using a liquid cyclotron target. We Investigated the yield of cyclotron-produced 68 …

Multi-curie production of gallium-68 on a biomedical cyclotron and automated radiolabelling of PSMA-11 and DOTATATE

H Thisgaard, J Kumlin, N Langkjær, J Chua… - EJNMMI radiopharmacy …, 2021 - Springer
Background With increasing clinical demand for gallium-68, commercial germanium-
68/gallium-68 ([68 Ge] Ge/[68 Ga] Ga) generators are incapable of supplying sufficient …

Prospects for the production of radioisotopes and radiobioconjugates for theranostics

J Choiński, M Łyczko - Bio-Algorithms and Med-Systems, 2022 - degruyter.com
The development of diagnostic methods in medicine as well as the progress in the synthesis
of biologically active compounds allows the use of selected radioisotopes for the …

[HTML][HTML] Cyclotron production of PET radiometals in liquid targets: Aspects and prospects

MK Pandey, TR DeGrado - Current radiopharmaceuticals, 2021 - ncbi.nlm.nih.gov
The present review describes the methodological aspects and prospects of the production of
Positron Emission Tomography (PET) radiometals in a liquid target using low-medium …

Antibody and Nanobody Radiolabeling with Copper-64: Solid vs. Liquid Target Approach

I Hrynchak, D Cocioabă, AI Fonseca, R Leonte… - Molecules, 2023 - mdpi.com
Antibody and nanobody-based copper-64 radiopharmaceuticals are increasingly being
proposed as theranostic tools in multiple human diseases. While the production of copper …

Production of GMP-compliant clinical amounts of Copper-61 radiopharmaceuticals from liquid targets

AI Fonseca, VH Alves, SJC do Carmo, M Silva… - Pharmaceuticals, 2022 - mdpi.com
PET imaging has gained significant momentum in the last few years, especially in the area
of oncology, with an increasing focus on metal radioisotopes owing to their versatile …

Rapid and automated production of [68Ga] gallium chloride and [68Ga] Ga-DOTA-TATE on a medical cyclotron

W Tieu, CA Hollis, KKW Kuan, P Takhar… - Nuclear Medicine and …, 2019 - Elsevier
Abstract Introduction The demand for Gallium-68 (68 Ga) for labelling PET
radiopharmaceuticals has increased over the past few years. 68 Ga is obtained through the …

[HTML][HTML] Recent Advances in Preclinical Studies of the Theranostic Agent [64Cu]CuCl2

G Speltri, F Porto, A Boschi, L Uccelli, P Martini - Molecules, 2024 - mdpi.com
64Cu is gaining recognition not only for its diagnostic capabilities in nuclear medical
imaging but also for its therapeutic and theranostic potential. The simultaneous βˉ and …