Homologous recombination (HR) is critical both for repairing DNA lesions in mitosis and for
chromosomal pairing and exchange during meiosis. However, some forms of HR can also …

For decades, lower-model organisms such as Drosophila melanogaster have often provided
the first glimpse into the mechanism of action of human cancer-related proteins, thus making …

This report of independent genome sequences of two natural populations of Drosophila
melanogaster (37 from North America and 6 from Africa) provides unique insight into forces …

Drosophila oogenesis was initially studied for its role in patterning the embryo, but it has
since become a powerful model system for investigating many aspects of cell and …

Gametes are highly specialized cell types produced by a complex differentiation process.
Production of viable oocytes requires a series of precise and coordinated molecular events …

Fanconi anemia (FA) is a life-threatening syndrome characterized by bone marrow failure
and cancer predispositions. The past two decades have seen an explosion of data in the FA …

RAD51 recombinase plays a central role in homologous recombination (HR) by forming a
nucleoprotein filament on single-stranded DNA (ssDNA) to catalyze homology search and …

mRNA localization, and translation that is regulated spatially and temporally, are key
mechanisms in the execution of polarized developmental programs. For over two decades …

The causes of ovarian dysgenesis remain incompletely understood. Two sisters with XX
ovarian dysgenesis carried compound heterozygous truncating mutations in the BRCA2 …

Genetic recombination is important for generating diversity and to ensure faithful
segregation of chromosomes at meiosis. However, few crossovers (COs) are formed per …