Extracellular vesicles: emerging roles, biomarkers and therapeutic strategies in fibrotic diseases

J Zhu, S Wang, D Yang, W Xu, H Qian - Journal of Nanobiotechnology, 2023 - Springer
Extracellular vesicles (EVs), a cluster of cell-secreted lipid bilayer nanoscale particles,
universally exist in body fluids, as well as cell and tissue culture supernatants. Over the past …

Extracellular vesicles and their cells of origin: Open issues in autoimmune diseases

A Haghighitalab, M Dominici, MM Matin… - Frontiers in …, 2023 - frontiersin.org
The conventional therapeutic approaches to treat autoimmune diseases through
suppressing the immune system, such as steroidal and non-steroidal anti-inflammatory …

Extracellular vesicles as carriers for mitochondria: Biological functions and clinical applications

Z Liao, B Tong, W Ke, C Yang, X Wu, M Lei - Mitochondrion, 2024 - Elsevier
In recent years, research has increasingly focused on the biogenesis of extracellular
vesicles (EVs) and the sorting mechanisms for their contents. Mitochondria can be …

Small RNA-big impact: exosomal miRNAs in mitochondrial dysfunction in various diseases

X Li, Y Han, Y Meng, L Yin - RNA biology, 2024 - Taylor & Francis
Mitochondria are multitasking organelles involved in maintaining the cell homoeostasis.
Beyond its well-established role in cellular bioenergetics, mitochondria also function as …

(+)‐Catechins Play a Protective Role in Diabetic Kidney Disease by Alleviating EMT through Multiple Pathways

Y Ni, D Zhu, C Chen, F Wang, Y Miu… - Molecular Nutrition & …, 2024 - Wiley Online Library
Scope Diabetic nephropathy (DN), a complication of diabetes mellitus, is becoming a
significant global health concern, with no complete cure currently available. Tea is regarded …

Mitochondrial impairment: a link for inflammatory responses activation in the cardiorenal syndrome type 4

I Amador-Martínez, OE Aparicio-Trejo… - International Journal of …, 2023 - mdpi.com
Cardiorenal syndrome type 4 (CRS type 4) occurs when chronic kidney disease (CKD)
leads to cardiovascular damage, resulting in high morbidity and mortality rates …

Dynamic changes in extracellular vesicle-associated miRNAs elicited by ultrasound in inflammatory bowel disease patients

F Tran, A Scharmacher, N Baran, N Mishra… - Scientific Reports, 2024 - nature.com
Blood-based biomarkers that reliably indicate disease activity in the intestinal tract are an
important unmet need in the management of patients with IBD. Extracellular vesicles (EVs) …

Exosomal noncoding RNA: A potential therapy for retinal vascular diseases

JI Heo, J Ryu - Molecular Therapy-Nucleic Acids, 2024 - cell.com
Exosomes are extracellular vesicles that can contain DNA, RNA, proteins, and metabolites.
They are secreted by cells and play a regulatory role in various biological responses by …

miRNAs in the Box: Potential Diagnostic Role for Extracellular Vesicle-Packaged miRNA-27a and miRNA-128 in Breast Cancer

C Giordano, FM Accattatis, L Gelsomino… - International Journal of …, 2023 - mdpi.com
Circulating extracellular vesicle (EV)-derived microRNAs (miRNAs) are now considered the
next generation of cancer “theranostic” tools, with strong clinical relevance. Although their …

ENGINEERING A GENETICALLY-ENCODABLE TOOLKIT FOR TRACKING EVS AND THEIR RNA CARGO

E Bonacquisti - 2022 - cdr.lib.unc.edu
Exosomes and extracellular vesicles (EVs) are endogenous lipid vesicles that carryRNA,
protein, and lipids to mediate both paracrine and long-distance signaling. EVshave been …