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Daily dietary potassium (K+) intake may be as large as the extracellular K+ pool. To avoid
acute hyperkalemia, rapid removal of K+ from the extracellular space is essential. This is …

Consumption of low dietary potassium, common with ultraprocessed foods, activates the
thiazide-sensitive sodium chloride cotransporter (NCC) via the w ith no (K) lysine …

The distal convoluted tubule is the nephron segment that lies immediately downstream of
the macula densa. Although short in length, the distal convoluted tubule plays a critical role …

A dietary potassium load induces a rapid kaliuresis and natriuresis, which may occur even
before plasma potassium and aldosterone (aldo) levels increase. Here we sought to gain …

Abstract The Na+-Cl− cotransporter (NCC) drives salt reabsorption in the kidney and plays a
decisive role in balancing electrolytes and blood pressure. Thiazide and thiazide-like …

Targeting the collecting duct water channel aquaporin 2 (AQP2) to the plasma membrane is
essential for the maintenance of mammalian water homeostasis. The vasopressin V2 …

The SLC12 family encodes electroneutral cation-coupled chloride cotransporters that are
critical for several physiological processes including cell volume regulation, modulation of …

The distal tubule of the mammalian kidney can be defined as the nephron segment between
the macula densa region and the cortical collecting tubule. It comprises several …

Regulation of renal Na+ transport is essential for controlling blood pressure, as well as Na+
and K+ homeostasis. Aldosterone stimulates Na+ reabsorption by the Na+-Cl− cotransporter …