β-Endorphins are peptides that exert a wide variety of effects throughout the body. Produced
through the cleavage pro-opiomelanocortin (POMC), β-endorphins are the primarily agonist …

Obesity is a multifactorial and complex disease that often manifests in early childhood with a
lifelong burden. Polygenic and monogenic obesity are driven by the interaction between …

Heterogeneity of lung tumor endothelial cell (TEC) phenotypes across patients, species
(human/mouse), and models (in vivo/in vitro) remains poorly inventoried at the single-cell …

Within eukaryotic cells, translation is regulated independent of transcription, enabling
nuanced, localized, and rapid responses to stimuli. Neurons respond transcriptionally and …

The central amygdala (CeA) contains a diverse population of cells, including multiple
subtypes of GABAergic neurons, along with glia and epithelial cells. Specific CeA cell types …

Proper intracellular trafficking is essential for neuronal development and function, and when
any aspect of this process is dysregulated, the resulting “transportopathy” causes …

Peptide hormones are first produced as larger precursor prohormones that require
endoproteolytic cleavage to liberate the mature hormones. A structurally conserved but …

Obesity and type 2 diabetes (T2D) are the leading causes of the progressive decline in
muscle regeneration and fitness in adults. The muscle microenvironment is known to play a …

Enteroendocrine cells (EECs) secrete hormones in response to ingested nutrients to control
physiological processes such as appetite and insulin release. EEC hormones are …

Introduction MicroRNAs (miRNAs) are single RNA molecules that act as global regulators of
gene expression in mammalian cells and thus constitute attractive targets in treating cancer …