Novel cocrystals of itraconazole: Insights from phase diagrams, formation thermodynamics and solubility
In this work, the cocrystallization approach was applied to itraconazole (ITR), a very slightly
soluble triazole antifungal drug, which led to the formation of two new solid forms of ITR with …
soluble triazole antifungal drug, which led to the formation of two new solid forms of ITR with …
Melting points of one-and two-component molecular crystals as effective characteristics for rational design of pharmaceutical systems
G Perlovich - Acta Crystallographica Section B: Structural Science …, 2020 - journals.iucr.org
Based on the review of the literature results the database of the fusion temperatures of two-
component molecular crystals (1947 co-crystals) and individual components thereof was …
component molecular crystals (1947 co-crystals) and individual components thereof was …
Identification of a previously unreported co-crystal form of acetazolamide: a combination of multiple experimental and virtual screening methods
In the search for new co-crystal forms, many studies only consider one method of co-
crystallisation which may lead to incorrect results. In this work, we demonstrate the efficiency …
crystallisation which may lead to incorrect results. In this work, we demonstrate the efficiency …
Ciprofloxacin salts with benzoic acid derivatives: structural aspects, solid-state properties and solubility performance
In this work, three new pharmaceutical hydrated salts of ciprofloxacin with selected
derivatives of benzoic acid, namely 4-hydroxybenzoic acid, 4-aminobenzoic acid and gallic …
derivatives of benzoic acid, namely 4-hydroxybenzoic acid, 4-aminobenzoic acid and gallic …
Thermal method usage features for multicomponent crystal screening
In this work, the effectiveness of thermal methods, liquid-assisted grinding (LAG), and
crystallization by a slow evaporation technique for the screening of multicomponent crystals …
crystallization by a slow evaporation technique for the screening of multicomponent crystals …
Bimetallic Au–Pd nanoparticles supported on silica with a tunable core@ shell structure: enhanced catalytic activity of Pd (core)–Au (shell) over Au (core)–Pd (shell)
A facile ligand-assisted approach of synthesizing bimetallic Au–Pd nanoparticles supported
on silica with a tunable core@ shell structure is presented. Maneuvering the addition …
on silica with a tunable core@ shell structure is presented. Maneuvering the addition …
Comparative analysis of experimental methods for determining thermodynamic parameters of formation of multi-component molecular crystals: Benefits and limitations
In this work, we have studied the processes of dissolution of 4-aminobenzoic acid (PABA)
two-component crystals with 6-methyluracil (6-MeUr), pyrazinamide (PyrAm) and emoxypine …
two-component crystals with 6-methyluracil (6-MeUr), pyrazinamide (PyrAm) and emoxypine …
Gibbs Formation Energy of a Cocrystal that Dissociates into a Hydrate
S Khope, S Pal - Crystal Growth & Design, 2022 - ACS Publications
The Gibbs energy of formation, Δ G f, of a cocrystal is a fundamental property to determine its
thermodynamic stability. One of the methods to determine Δ G f is from the eutectic …
thermodynamic stability. One of the methods to determine Δ G f is from the eutectic …
Invariant and variable supramolecular self-assembly in 6-substituted uracil derivatives: Insights from X-ray structures and quantum chemical study
LH Al-Wahaibi, SRS Bysani, SS Tawfik… - Crystal Growth & …, 2021 - ACS Publications
In this study, three new 6-(arylthio) uracil derivatives, namely, 6-(phenylthio) pyrimidine-2, 4
(1 H, 3 H)-dione (1), C10H8N2O2S; 6-(p-tolylthio) pyrimidine-2, 4 (1 H, 3 H)-dione (2) …
(1 H, 3 H)-dione (1), C10H8N2O2S; 6-(p-tolylthio) pyrimidine-2, 4 (1 H, 3 H)-dione (2) …
Supramolecular architectures, Hirshfeld surface analysis of 2-Amino 4-methyl pyridinium 4 amino salicylate and 2-Amino 4-methyl pyridinium 5 chloro salicylate
S Suresh, K Ammasai, K Chinnasamy… - Chemical Data …, 2021 - Elsevier
In the present study, crystals of two salts were grown by mixing of 2-Amino 4-methyl pyridine
(2AMP) with 4-amino salicylic acid (4ASA)(C 6 H 9 N 2+ C 7 H 6 NO 3− Salt-I) and 5‑chloro …
(2AMP) with 4-amino salicylic acid (4ASA)(C 6 H 9 N 2+ C 7 H 6 NO 3− Salt-I) and 5‑chloro …