Restless legs syndrome (RLS) is a common sensorimotor disorder characterized by an urge
to move that appears during rest or is exacerbated by rest, that occurs in the evening or night …

Background: Multiple sclerosis (MS), a subset of chronic primary inflammatory demyelinating
disorders of the central nervous system, is closely associated with various movement …

Current evidence suggests that iron deficiency (ID) plays a key role in the pathogenesis of
conditions presenting with restlessness such as attention deficit hyperactivity disorder …

Restless legs syndrome (RLS) is responsive to opioid, dopaminergic and iron-based
treatments. Receptor blocker studies in RLS patients suggest that the therapeutic efficacy of …

Our understanding of the causes and natural course of restless legs syndrome (RLS) is
incomplete. The lack of objective diagnostic biomarkers remains a challenge for clinical …

Restless legs syndrome (RLS) is a sensorimotor disorder with a obvious circadian rhythm,
as its symptoms often occur or worsen only in the evening or at night. The mechanisms …

Purpose We performed comparative proteomic analyses of blood of patients with RLS and
healthy individuals aiming to identify potential biomarker and therapeutic target candidate …

Study objectives Studies on brain iron content in restless legs syndrome (RLS) using
magnetic resonance imaging (MRI) are heterogeneous. In this study, we sought to leverage …

Objectives We used a high-throughput assay of 5000 plasma proteins to identify biomarkers
associated with periodic limb movements (PLM) and restless legs syndrome (RLS) in adults …

Abstract Background Restless Legs Syndrome (RLS) is a neurological sensorimotor
disorder that occurs in the evening and night, thereby often impacting quality of sleep in …