Sphingolipids are highly enriched in the nervous system where they are pivotal constituents
of the plasma membranes and are important for proper brain development and functions …

Oligodendrocytes are the myelinating cells of the central nervous system (CNS). They are
the end product of a cell lineage which has to undergo a complex and precisely timed …

Efficient and rapid propagation of action potentials in myelinated axons depends on the
molecular specialization of the nodes of Ranvier. The nodal region is organized into several …

In myelinated axons, K+ channels are concealed under the myelin sheath in the
juxtaparanodal region, where they are associated with Caspr2, a member of the neurexin …

Oligodendrocytes (OLs) are mature glial cells that myelinate axons in the brain and spinal
cord. As such, they are integral to functional and efficient neuronal signaling. The embryonic …

Potassium channels (KChs) are the most diverse ion channels, in part due to extensive
combinatorial assembly of a large number of principal and auxiliary subunits into an …

Myelinated fibers are organized into distinct domains that are necessary for saltatory
conduction. These domains include the nodes of Ranvier and the flanking paranodal …

Rapid nerve impulse conduction depends on specialized membrane domains in myelinated
nerve, the node of Ranvier, the paranode, and the myelinated internodal region. We report …

Auto-antibodies against the paranodal proteins neurofascin-155 and contactin-1 have
recently been described in patients with chronic inflammatory demyelinating …

Nervonic acid, a 24-carbon fatty acid with only one double bond at the 9th carbon (C24: 1n-
9), is abundant in the human brain, liver, and kidney. It not only functions in free form but …