Making target sites in large structured RNAs accessible to RNA-cleaving DNAzymes through hybridization with synthetic DNA oligonucleotides
The 10–23 DNAzyme is one of the most active DNA-based enzymes, and in theory, can be
designed to target any purine-pyrimidine junction within an RNA sequence for cleavage …
designed to target any purine-pyrimidine junction within an RNA sequence for cleavage …
Biomathematical enzyme kinetics model of prebiotic autocatalytic RNA networks: degenerating parasite-specific hyperparasite catalysts confer parasite resistance and …
M Pirovino, C Iseli, JA Curran, B Conrad - bioRxiv, 2024 - biorxiv.org
Catalysis and specifically autocatalysis are the quintessential building blocks of life. Yet,
although autocatalytic networks are necessary, they are not sufficient for the emergence of …
although autocatalytic networks are necessary, they are not sufficient for the emergence of …
A polymerase ribozyme that can synthesize both itself and its complementary strand
The emergence of a chemical system capable of self-replication and evolution is a critical
event in the origin of life. RNA polymerase ribozymes could constitute such a system, but …
event in the origin of life. RNA polymerase ribozymes could constitute such a system, but …