Adjuvants incorporated in prophylactic and/or therapeutic vaccine formulations impact
vaccine efficacy by enhancing, modulating, and/or prolonging the immune response. In …

Vaccines were initially developed on an empirical basis, relying mostly on attenuation or
inactivation of pathogens. Advances in immunology, molecular biology, biochemistry …

Despite intensive long-term efforts, with very few exceptions, the development of effective
vaccines against parasitic infections has presented considerable challenges, given the …

Parasitic helminths infect over one-fourth of the human population resulting in significant
morbidity, and in some cases, death in endemic countries. Despite mass drug administration …

Research over the past several decades has provided insight into the mode of action of
adjuvants. However, the main focus of attention has been the efficacy in the induction of …

Vaccines are considered the most economical and effective preventive measure against
most deadly infectious diseases. Vaccines help protect around three million lives every year …

Coccidial parasites cause medical and veterinary diseases worldwide, frequently leading to
severe illness and important economic losses. At present, drugs, chemotherapeutics and …

Abstract Background The Receptor Binding Domain (RBD) of the SARS-CoV-2 spike protein
is the target for many COVID-19 vaccines. Here we report results for phase I clinical trial of …

Local reactions are the most frequent adverse event associated with vaccines. Adjuvants are
major constituents of many vaccines and they are frequently involved in these reactions …

The first leptospiral recombinant vaccine was developed in the late 1990s. Since then,
progress in the fields of reverse vaccinology (RV) and structural vaccinology (SV) has …