Structure, assembly, and function of tripartite efflux and type 1 secretion systems in gram-negative bacteria
Tripartite efflux pumps and the related type 1 secretion systems (T1SSs) in Gram-negative
organisms are diverse in function, energization, and structural organization. They form …
organisms are diverse in function, energization, and structural organization. They form …
The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria
The global emergence of multidrug-resistant Gram-negative bacteria is a growing threat to
antibiotic therapy. The chromosomally encoded drug efflux mechanisms that are ubiquitous …
antibiotic therapy. The chromosomally encoded drug efflux mechanisms that are ubiquitous …
Metagenomic and network analysis reveal wide distribution and co-occurrence of environmental antibiotic resistance genes
A metagenomic approach and network analysis was used to investigate the wide-spectrum
profiles of antibiotic resistance genes (ARGs) and their co-occurrence patterns in 50 …
profiles of antibiotic resistance genes (ARGs) and their co-occurrence patterns in 50 …
Metagenomics of urban sewage identifies an extensively shared antibiotic resistome in China
Background Antibiotic-resistant pathogens are challenging treatment of infections
worldwide. Urban sewage is potentially a major conduit for dissemination of antibiotic …
worldwide. Urban sewage is potentially a major conduit for dissemination of antibiotic …
[HTML][HTML] Structure of the AcrAB–TolC multidrug efflux pump
The capacity of numerous bacterial species to tolerate antibiotics and other toxic compounds
arises in part from the activity of energy-dependent transporters. In Gram-negative bacteria …
arises in part from the activity of energy-dependent transporters. In Gram-negative bacteria …
Multidrug resistance in bacteria
H Nikaido - Annual review of biochemistry, 2009 - annualreviews.org
Large amounts of antibiotics used for human therapy, as well as for farm animals and even
for fish in aquaculture, resulted in the selection of pathogenic bacteria resistant to multiple …
for fish in aquaculture, resulted in the selection of pathogenic bacteria resistant to multiple …
An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump
Bacterial efflux pumps confer multidrug resistance by transporting diverse antibiotics from
the cell. In Gram-negative bacteria, some of these pumps form multi-protein assemblies that …
the cell. In Gram-negative bacteria, some of these pumps form multi-protein assemblies that …
Efflux-mediated drug resistance in bacteria: an update
XZ Li, H Nikaido - Drugs, 2009 - Springer
Drug efflux pumps play a key role in drug resistance and also serve other functions in
bacteria. There has been a growing list of multidrug and drug-specific efflux pumps …
bacteria. There has been a growing list of multidrug and drug-specific efflux pumps …
Efflux pump inhibitors of clinically relevant multidrug resistant bacteria
A Lamut, L Peterlin Mašič, D Kikelj… - Medicinal Research …, 2019 - Wiley Online Library
Bacterial infections are an increasingly serious issue worldwide. The inability of existing
therapies to treat multidrug‐resistant pathogens has been recognized as an important …
therapies to treat multidrug‐resistant pathogens has been recognized as an important …
Antibiotic resistance mediated by the MacB ABC transporter family: a structural and functional perspective
The MacB ABC transporter forms a tripartite efflux pump with the MacA adaptor protein and
TolC outer membrane exit duct to expel antibiotics and export virulence factors from Gram …
TolC outer membrane exit duct to expel antibiotics and export virulence factors from Gram …