Activated B cells participate in either extrafollicular (EF) or germinal center (GC) responses.
Canonical responses are composed of a short wave of plasmablasts (PBs) arising from EF …

Germinal centers (GCs) are the site of antibody diversification and affinity maturation and as
such are vitally important for humoral immunity. The study of GC biology has undergone a …

Therapeutic targeting of immune checkpoints has garnered significant attention in the area
of cancer immunotherapy, in which efforts have focused in particular on cytotoxic T …

Recent work has provided new insights into how altered B cell-intrinsic signals—through the
B cell receptor (BCR) and key co-receptors—function together to promote the pathogenesis …

High affinity antibodies result from interactions between B cells and T follicular helper (Tfh)
cells in germinal centers (GCs). Recent studies have identified an effector subset of T …

The successful establishment of humoral memory response depends on at least two layers
of defense. Pre‐existing protective antibodies secreted by long‐lived plasma cells act as a …

NF-κB signaling is essential to an effective innate and adaptive immune response. Many
immune-specific functional and developmental outcomes depend in large on NF-κB. The …

The B cell-stimulating molecules, BAFF (B cell activating factor) and APRIL (a proliferation-
inducing ligand), are critical factors in the maintenance of the B cell pool and humoral …

Highlights•TACI promotes TI antibody responses and controls autoimmunity and
lymphoproliferation.•TACI integrates signals from multiple pathways in B-cells to regulate …

Germinal centers (GCs) are the sites where B cells undergo affinity maturation. The
regulation of cellular output from the GC is not well understood. Here, we show that from the …