Abstract Twenty-(S)-camptothecin is a strongly cytotoxic molecule with excellent antitumor
activity over a wide spectrum of human cancers. However, the direct formulation is limited by …

Camptothecin (CPT) and its derivatives comprise an important group of heterocyclic
compounds that are well recognized for their anticancer activities. Efforts have been made …

Malignant tumor cells have been found to have high levels of reactive oxygen species such
as hydrogen peroxide (H 2 O 2), supporting the hypothesis that a prodrug could be activated …

The stereoselective preparation of diosgenin-derived thio (seleno) ureas and glycomimetics
bearing a 1, 2, 3-triazolyl tether on C-3 has been accomplished. The key steps in the …

Abstract Non-protected 2, 5-diketopiperazine derivatives have poor solubility thus with
negative impact on their bioavailability. In the present study, twenty-one novel soluble mono …

Topoisomerases are interesting targets for drug discovery. In the present study, we attached
saturated carbon atoms to the 10-position of camptothecin and synthesized 10 new …

We designed new hypoxia-activated prodrugs by conjugating (1-methyl-2-nitro-1 H-imidazol-
5-yl) methanol with 7-ethyl-10-hydroxy camptothecin (SN-38). Initially, we improved the …

Camptothecin (CPT), obtained from Camptotheca acuminata (Nyssaceae), is a quinoline
type of alkaloid. Apart from various traditional uses, it is mainly used as a potential cytotoxic …

Due to the low esterase activity in human plasma, many ester and carbonate prodrugs
tested in humans may be less effective than that in preclinical animals. In this letter, PTX and …

Natural products are a rich source of bioactive compounds, and numerous natural
compounds have found application in cancer chemotherapy. However, unfavorable …