Synthetic organic electrochemical methods since 2000: on the verge of a renaissance

M Yan, Y Kawamata, PS Baran - Chemical Reviews, 2017 - ACS Publications
Electrochemistry represents one of the most intimate ways of interacting with molecules. This
review discusses advances in synthetic organic electrochemistry since 2000. Enabling …

Electrosynthetic C− O bond activation in alcohols and alcohol derivatives

P Villo, A Shatskiy, MD Kärkäs… - Angewandte Chemie …, 2023 - Wiley Online Library
Alcohols and their derivatives are ubiquitous and versatile motifs in organic synthesis.
Deoxygenative transformations of these compounds are often challenging due to the …

Practical and General Alcohol Deoxygenation Protocol

OP Williams, AF Chmiel, M Mikhael… - Angewandte Chemie …, 2023 - Wiley Online Library
Herein, we describe a practical protocol for the removal of alcohol functional groups through
reductive cleavage of their benzoate ester analogs. This transformation requires a strong …

Electrosynthesis using carboxylic acid derivatives: new tricks for old reactions

MC Leech, K Lam - Accounts of Chemical Research, 2020 - ACS Publications
Conspectus Electrosynthetic organic chemistry is an old discipline that takes its root in
Faraday's seminal works. The field has a rich history and is in the midst of a renaissance …

Recent advances in the chemoselective reduction of functional groups mediated by samarium (II) iodide: a single electron transfer approach

M Szostak, M Spain, DJ Procter - Chemical Society Reviews, 2013 - pubs.rsc.org
Recently, samarium (II) iodide reductants have emerged as powerful single electron donors
for the highly chemoselective reduction of common functional groups. Complete control of …

Photoredox‐Catalyzed Deoxygenation of Hexafluoroacetone Hydrate Enables Hydroxypolyfluoroalkylation of Alkenes

ZZ Xie, Y Zheng, CP Yuan, JP Guan, ZP Ye… - Angewandte …, 2022 - Wiley Online Library
An unprecedented photoredox‐catalyzed phosphine‐mediated deoxygenation of
hexafluoroacetone hydrate was established to accomplish the hydroxylpolyfluoroalkylation …

Metal-free deoxygenative coupling of alcohol-derived benzoates and pyridines for small molecules and DNA-encoded libraries synthesis

SRN Kolusu, M Nappi - Chemical Science, 2022 - pubs.rsc.org
Alcohols are among the most widely occurring functional groups found in naturally
abundant, biologically relevant organic compounds, which in many cases are considered …

Sm (II)-mediated electron transfer to carboxylic acid derivatives: development of complexity-generating cascades

X Just-Baringo, DJ Procter - Accounts of Chemical Research, 2015 - ACS Publications
Conspectus Reductive electron transfer (ET) to organic compounds is a powerful method for
the activation of substrates via the formation of radicals, radical anions, anions, and dianions …

Radical Deoxyfunctionalisation Strategies

K Anwar, K Merkens, FJ Aguilar Troyano… - European Journal of …, 2022 - Wiley Online Library
Due to their abundance and readily available synthesis, alcohols provide ideal handles for
the selective derivatisation of organic molecules. Radical chemistry offers versatile …

Evolution of neutral organic super-electron-donors and their applications

E Doni, JA Murphy - Chemical Communications, 2014 - pubs.rsc.org
In recent times, metal-free chemistry has received significant attention due to its inherent
qualities and its potential savings in the costs of (i) reagents and (ii) environmental …