Abstract Chalcone or (E)-1, 3-diphenyl-2-propene-1-one scaffold remained a fascination
among researchers in the 21st century due to its simple chemistry, ease of synthesis and a …

Chalcones are a class of privileged scaffolds with high medicinal significance due to the
presence of an α, β-unsaturated ketone functionality. Numerous functional modifications of …

Chalcones are naturally occurring compounds exhibiting broad spectrum biological
activities including anticancer activity through multiple mechanisms. Literature on anticancer …

The continuous emergency of drug‐resistant cancers and the low specificity of anticancer
agents have been the major challenges in the control and treatment of cancer, making an …

Heterocyclic compounds hold a pivotal place in medicinal chemistry due to their wide range
of biological activities and thus, are exhaustively explored in the field of drug design and …

The introduction of poly (dimethylsiloxane)(PDMS) and soft lithography in the 90's has
revolutionized the field of microfluidics by almost eliminating the need for a clean-room …

The current study was directed toward developing a new series of fused heterocycles
incorporating indazolylthiazole moiety. The newly synthesized compounds were …

Many literature reports revealed the anticancer activity of pyridine and thiazole derivatives,
especially in lung cancer. Therefore, a new series of thiazolyl pyridines linked with …

Investigating novel compounds that may be useful in designing new, less toxic, selective,
and potent breast anticancer agents is still the main challenge for medicinal chemists. Thus …

The p53 protein is one of the most important tumor suppressors that are frequently
inactivated in cancer cells. This inactivation occurs either because the TP53 gene is mutated …