Nonspecific binding—fundamental concepts and consequences for biosensing applications

A Frutiger, A Tanno, S Hwu, RF Tiefenauer… - Chemical …, 2021 - ACS Publications
Nature achieves differentiation of specific and nonspecific binding in molecular interactions
through precise control of biomolecules in space and time. Artificial systems such as …

Biological nanopore approach for single‐molecule protein sequencing

ZL Hu, MZ Huo, YL Ying, YT Long - Angewandte Chemie, 2021 - Wiley Online Library
Proteins are responsible for the occurrence and treatment of many diseases, and therefore
protein sequencing will revolutionize proteomics and clinical diagnostics. Biological …

Single Molecule Ratcheting Motion of Peptides in a Mycobacterium smegmatis Porin A (MspA) Nanopore

S Yan, J Zhang, Y Wang, W Guo, S Zhang, Y Liu… - Nano …, 2021 - ACS Publications
Diverse functions of proteins, including synthesis, catalysis, and signaling, result from their
highly variable amino acid sequences. The technology allowing for direct analysis of protein …

Cancer biomarker detection: recent achievements and challenges

L Wu, X Qu - Chemical Society Reviews, 2015 - pubs.rsc.org
The early detection of cancer can significantly reduce cancer mortality and saves lives. Thus,
a great deal of effort has been devoted to the exploration of new technologies to detect early …

Nanopore sensing

W Shi, AK Friedman, LA Baker - Analytical chemistry, 2017 - ACS Publications
Scope of the Review. Herein, we provide an up-to-date overview of the field of nanopore
sensing with emphases placed on the advances made in the most recent two years (2014 …

Electro-osmotic capture and ionic discrimination of peptide and protein biomarkers with FraC nanopores

G Huang, K Willems, M Soskine, C Wloka… - Nature …, 2017 - nature.com
Biological nanopores are nanoscale sensors employed for high-throughput, low-cost, and
long read-length DNA sequencing applications. The analysis and sequencing of proteins …

Nanopore-based single-biomolecule interfaces: from information to knowledge

YL Ying, YT Long - Journal of the American Chemical Society, 2019 - ACS Publications
Single-molecule measurements have greatly enhanced our understanding of living systems.
Biological systems offer nanopores, a sub-class of membrane proteins, the well-defined …

Portable nanopore-sequencing technology: Trends in development and applications

P Chen, Z Sun, J Wang, X Liu, Y Bai, J Chen… - Frontiers in …, 2023 - frontiersin.org
Sequencing technology is the most commonly used technology in molecular biology
research and an essential pillar for the development and applications of molecular biology …

Nanopore detection of metal ions: current status and future directions

GM Roozbahani, X Chen, Y Zhang, L Wang… - Small …, 2020 - Wiley Online Library
In this review, recent research efforts that aimed at developing nanopore sensors for
detection of metal ions, which play a crucial role in environmental safety and human health …

Specific Detection of Proteins by a Nanobody-Functionalized Nanopore Sensor

X Zhang, NS Galenkamp, NJ van der Heide… - ACS …, 2023 - ACS Publications
Nanopores are label-free single-molecule analytical tools that show great potential for
stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with …