Viral membrane fusion: a dance between proteins and lipids
There are at least 21 families of enveloped viruses that infect mammals, and many contain
members of high concern for global human health. All enveloped viruses have a dedicated …
members of high concern for global human health. All enveloped viruses have a dedicated …
[HTML][HTML] HIV-1 entry and membrane fusion inhibitors
HIV-1 (human immunodeficiency virus type 1) infection begins with the attachment of the
virion to a host cell by its envelope glycoprotein (Env), which subsequently induces fusion of …
virion to a host cell by its envelope glycoprotein (Env), which subsequently induces fusion of …
[PDF][PDF] Cryo-ET of Env on intact HIV virions reveals structural variation and positioning on the Gag lattice
HIV-1 Env mediates viral entry into host cells and is the sole target for neutralizing
antibodies. However, Env structure and organization in its native virion context has eluded …
antibodies. However, Env structure and organization in its native virion context has eluded …
Breathing and tilting: mesoscale simulations illuminate influenza glycoprotein vulnerabilities
L Casalino, C Seitz, J Lederhofer… - ACS Central …, 2022 - ACS Publications
Influenza virus has resurfaced recently from inactivity during the early stages of the COVID-
19 pandemic, raising serious concerns about the nature and magnitude of future epidemics …
19 pandemic, raising serious concerns about the nature and magnitude of future epidemics …
[HTML][HTML] Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5
Pdr5, a member of the extensive ABC transporter superfamily, is representative of a clinically
relevant subgroup involved in pleiotropic drug resistance. Pdr5 and its homologues drive …
relevant subgroup involved in pleiotropic drug resistance. Pdr5 and its homologues drive …
[HTML][HTML] Asymmetric conformations of cleaved HIV-1 envelope glycoprotein trimers in styrene-maleic acid lipid nanoparticles
During virus entry, the pretriggered human immunodeficiency virus (HIV-1) envelope
glycoprotein (Env) trimer initially transits into a default intermediate state (DIS) that remains …
glycoprotein (Env) trimer initially transits into a default intermediate state (DIS) that remains …
Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization
Rationally designed protein subunit vaccines are being developed for a variety of viruses
including influenza, RSV, SARS-CoV-2, and HIV. These vaccines are based on stabilized …
including influenza, RSV, SARS-CoV-2, and HIV. These vaccines are based on stabilized …
[HTML][HTML] Bringing immunofocusing into focus
S Musunuri, PAB Weidenbacher, PS Kim - npj Vaccines, 2024 - nature.com
Immunofocusing is a strategy to create immunogens that redirect humoral immune
responses towards a targeted epitope and away from non-desirable epitopes …
responses towards a targeted epitope and away from non-desirable epitopes …
Displaying and delivering viral membrane antigens via WW domain–activated extracellular vesicles
Membrane proteins expressed on the surface of enveloped viruses are conformational
antigens readily recognized by B cells of the immune system. An effective vaccine would …
antigens readily recognized by B cells of the immune system. An effective vaccine would …
Characterization of the human immunodeficiency virus (HIV-1) envelope glycoprotein conformational states on infectious virus particles
ABSTRACT Human immunodeficiency virus (HIV-1) entry into cells involves triggering of the
viral envelope glycoprotein (Env) trimer ([gp120/gp41] 3) by the primary receptor, CD4, and …
viral envelope glycoprotein (Env) trimer ([gp120/gp41] 3) by the primary receptor, CD4, and …