Altered metabolic patterns in tumor cells not only meet their own growth requirements but
also shape an immunosuppressive microenvironment through multiple mechanisms …

ATP is required for mammalian cells to remain viable and to perform genetically
programmed functions. Maintenance of the ΔG′ ATP hydrolysis of− 56 kJ/mole is the …

Homeostasis is one of the fundamental concepts in physiology. Despite remarkable
progress in our molecular understanding of amino acid transport, metabolism and signaling …

Ultrasound (US)-activated sonodynamic therapy (SDT) stands for a distinct antitumor
modality because of its attractive characteristics including intriguing noninvasiveness …

The unease of consumers with bisphenol A has led to the increased industrial usage of
bisphenol F (BPF), which is a new hazard to environmental health. Here, zebrafish were …

The inability to inspect metabolic activities within distinct subcellular compartments has been
a major barrier to our understanding of eukaryotic cell metabolism. Previous work addressed …

Immune checkpoint inhibition has transformed the treatment landscape of advanced
melanoma and long-term survival of patients is now possible. However, at least half of the …

Mammalian cells adapt their functional state in response to external signals in form of
ligands that bind receptors on the cell-surface. Mechanistically, this involves signal …

The availability of multi-omics data sets and genome-scale metabolic models for various
organisms provide a platform for modeling and analyzing genotype-to-phenotype …

After undergoing metabolic reprogramming, tumor cells consume additional glutamine to
produce amino acids, nucleotides, fatty acids, and other substances to facilitate their …