The stringent response and physiological roles of (pp) pGpp in bacteria
SE Irving, NR Choudhury, RM Corrigan - Nature Reviews Microbiology, 2021 - nature.com
The stringent response is a stress signalling system mediated by the alarmones guanosine
tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) in response to nutrient …
tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) in response to nutrient …
Fundamental principles in bacterial physiology—history, recent progress, and the future with focus on cell size control: a review
Bacterial physiology is a branch of biology that aims to understand overarching principles of
cellular reproduction. Many important issues in bacterial physiology are inherently …
cellular reproduction. Many important issues in bacterial physiology are inherently …
Principles of gene regulation quantitatively connect DNA to RNA and proteins in bacteria
Protein concentrations are set by a complex interplay between gene-specific regulatory
processes and systemic factors, including cell volume and shared gene expression …
processes and systemic factors, including cell volume and shared gene expression …
Residual guanosine 3 ', 5 '-bispyrophosphate synthetic activity of relA null mutants can be eliminated by spoT null mutations.
H Xiao, M Kalman, K Ikehara, S Zemel, G Glaser… - Journal of Biological …, 1991 - jbc.org
It was known previously that 1) the relA gene of Escherichia coli encodes an enzyme
capable of guanosine 3', 5'-bispyrophosphate (ppGpp) synthesis, 2) an uncharacterized …
capable of guanosine 3', 5'-bispyrophosphate (ppGpp) synthesis, 2) an uncharacterized …
The global, ppGpp‐mediated stringent response to amino acid starvation in Escherichia coli
MF Traxler, SM Summers, HT Nguyen… - Molecular …, 2008 - Wiley Online Library
The stringent response to amino acid starvation, whereby stable RNA synthesis is curtailed
in favour of transcription of amino acid biosynthetic genes, is controlled by the alarmone …
in favour of transcription of amino acid biosynthetic genes, is controlled by the alarmone …
Metabolism, cell growth and the bacterial cell cycle
Adaptation to fluctuations in nutrient availability is a fact of life for single-celled organisms in
the'wild'. A decade ago our understanding of how bacteria adjust cell cycle parameters to …
the'wild'. A decade ago our understanding of how bacteria adjust cell cycle parameters to …
Gene expression profiling of Escherichia coli growth transitions: an expanded stringent response model
DE Chang, DJ Smalley, T Conway - Molecular microbiology, 2002 - Wiley Online Library
When conditions cause bacterial growth to stop, extensive reprogramming of physiology and
gene expression allows for the cell's survival. We used whole‐genome DNA arrays to …
gene expression allows for the cell's survival. We used whole‐genome DNA arrays to …
Mutational analysis of the Escherichia coli spoT gene identifies distinct but overlapping regions involved in ppGpp synthesis and degradation
DR Gentry, M Cashel - Molecular microbiology, 1996 - Wiley Online Library
The spoT gene of Escherichia coli encodes a guanosine 3′, 5′‐bis (diphosphate) 3′‐
pyrophosphohydrolase (ppGppase) as well as an apparent guanosine 3′, 5′‐bis …
pyrophosphohydrolase (ppGppase) as well as an apparent guanosine 3′, 5′‐bis …
The cell cycle of Escherichia coli
WD Donachie - Annual review of microbiology, 1993 - go.gale.com
The growth of E. coli cells into a critical mass results in the formation of G-ring of a GTP-
binding protein (FtsZ) around the cell center. Chromosomal DNA replication is initiated at a …
binding protein (FtsZ) around the cell center. Chromosomal DNA replication is initiated at a …
Persistence of intracellular bacterial pathogens—With a focus on the metabolic perspective
W Eisenreich, T Rudel, J Heesemann… - Frontiers in Cellular and …, 2021 - frontiersin.org
Persistence has evolved as a potent survival strategy to overcome adverse environmental
conditions. This capability is common to almost all bacteria, including all human bacterial …
conditions. This capability is common to almost all bacteria, including all human bacterial …