The forkhead box O family consists of FoxO1, FoxO3, FoxO4 and FoxO6 proteins in
mammals. Expressed ubiquitously in the body, the four FoxO isoforms share in common the …

Lipid and carbohydrate metabolism are highly conserved processes that affect nearly all
aspects of organismal biology. Caenorhabditis elegans eat bacteria, which consist of lipids …

Aging happens to all of us as we live. Thanks to the improved living standard and discovery
of life-saving medicines, our life expectancy has increased substantially across the world in …

Redox biology is at the core of life sciences, accompanied by the close correlation of redox
processes with biological activities. Redox homeostasis is a prerequisite for human health …

Sustained mitochondrial fitness relies on coordinated biogenesis and clearance. Both
processes are regulated by constant targeting of proteins into the organelle. Thus …

Cellular metabolism is regulated by the mTOR kinase, a key component of the molecular
nutrient sensor pathway that plays a central role in cellular survival and aging. The mTOR …

Being overweight increases the risk of many metabolic disorders, but how it affects lifespan
is not completely clear. Not all obese people become ill, and the exact mechanism that turns …

Cellular senescence, a process in which a cell exits the cell cycle in response to stressors, is
one of the hallmarks of aging. Senescence and the senescence-associated secretory …

Methionine restriction (MetR) extends lifespan in various organisms, but its mechanistic
understanding remains incomplete. Whether MetR during a specific period of adulthood …

Klinefelter syndrome (KS) is the most common sex chromosomal disorder in males. Key
findings in older adolescents and young men are small testes with variable hypo …