3M-052, a synthetic TLR-7/8 agonist, induces durable HIV-1 envelope–specific plasma cells and humoral immunity in nonhuman primates
SP Kasturi, MAU Rasheed, C Havenar-Daughton… - Science …, 2020 - science.org
A fundamental challenge in vaccinology is learning how to induce durable antibody
responses. Live viral vaccines induce antibody responses that last a lifetime, but those …
responses. Live viral vaccines induce antibody responses that last a lifetime, but those …
Safety and immunogenicity of two heterologous HIV vaccine regimens in healthy, HIV-uninfected adults (TRAVERSE): a randomised, parallel-group, placebo …
LR Baden, DJ Stieh, M Sarnecki, SR Walsh… - The Lancet …, 2020 - thelancet.com
Background Bioinformatically designed mosaic antigens increase the breadth of HIV
vaccine-elicited immunity. This study compared the safety, tolerability, and immunogenicity …
vaccine-elicited immunity. This study compared the safety, tolerability, and immunogenicity …
Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates
The development of an effective AIDS vaccine remains a challenge. Nucleoside-modified
mRNAs formulated in lipid nanoparticles (mRNA-LNP) have proved to be a potent mode of …
mRNAs formulated in lipid nanoparticles (mRNA-LNP) have proved to be a potent mode of …
Advances in biomarker detection: Alternative approaches for blood-based biomarker detection
M Rosado, R Silva, MG Bexiga, JG Jones… - Advances in clinical …, 2019 - Elsevier
In the clinical setting, a blood sample is typically the starting point for biomarker search and
discovery. Mass spectrometry (MS) is a highly sensitive and informative method for …
discovery. Mass spectrometry (MS) is a highly sensitive and informative method for …
Measuring cellular immunity to influenza: methods of detection, applications and challenges
L Coughlan, T Lambe - Vaccines, 2015 - mdpi.com
Influenza A virus is a respiratory pathogen which causes both seasonal epidemics and
occasional pandemics; infection continues to be a significant cause of mortality worldwide …
occasional pandemics; infection continues to be a significant cause of mortality worldwide …
SMAC mimetic plus triple-combination bispecific HIVxCD3 retargeting molecules in SHIV. C. CH505-infected, antiretroviral therapy-suppressed rhesus macaques
A Dashti, C Waller, M Mavigner, N Schoof… - Journal of …, 2020 - Am Soc Microbiol
ABSTRACT The “shock-and-kill” human immunodeficiency virus type 1 (HIV-1) cure strategy
involves latency reversal followed by immune-mediated clearance of infected cells. We have …
involves latency reversal followed by immune-mediated clearance of infected cells. We have …
2022 White Paper on Recent Issues in Bioanalysis: Enzyme Assay Validation, BAV for Primary End Points, Vaccine Functional Assays, Cytometry in Tissue, LBA in …
G Sumner, S Keller, J Huleatt, RF Staack, L Wagner… - Bioanalysis, 2023 - Taylor & Francis
The 16th Workshop on Recent Issues in Bioanalysis (16th WRIB) took place in Atlanta, GA,
USA on September 26–30, 2022. Over 1000 professionals representing pharma/biotech …
USA on September 26–30, 2022. Over 1000 professionals representing pharma/biotech …
Diversity of antiviral IgG effector activities observed in HIV-infected and vaccinated subjects
Y Huang, G Ferrari, G Alter, DN Forthal… - The Journal of …, 2016 - journals.aai.org
Diverse Ab effector functions mediated by the Fc domain have been commonly associated
with reduced risk of infection in a growing number of nonhuman primate and human clinical …
with reduced risk of infection in a growing number of nonhuman primate and human clinical …
Cryopreservation-related loss of antigen-specific IFNγ producing CD4+ T-cells can skew immunogenicity data in vaccine trials: Lessons from a malaria vaccine trial …
T Ford, C Wenden, A Mbekeani, L Dally, JH Cox… - Vaccine, 2017 - Elsevier
Ex vivo functional immunoassays such as ELISpot and intracellular cytokine staining (ICS)
by flow cytometry are crucial tools in vaccine development both in the identification of novel …
by flow cytometry are crucial tools in vaccine development both in the identification of novel …
Toward optimal cryopreservation and storage for achievement of high cell recovery and maintenance of cell viability and T cell functionality
S Angel, H von Briesen, YJ Oh, MK Baller… - Biopreservation and …, 2016 - liebertpub.com
Cryopreservation of biological materials such as cells, tissues, and organs is a prevailing
topic of high importance. It is employed not only in many research fields but also in the …
topic of high importance. It is employed not only in many research fields but also in the …