Induction, regulation, degradation, and biological significance of mammalian metallothioneins

AT Miles, GM Hawksworth, JH Beattie… - Critical reviews in …, 2000 - Taylor & Francis
MTs are small cysteine-rich metal-binding proteins found in many species and, although
there are differences between them, it is of note that they have a great deal of sequence and …

[HTML][HTML] Cadmium and breast cancer–current state and research gaps in the underlying mechanisms

K Tarhonska, M Lesicka, B Janasik, J Roszak… - Toxicology Letters, 2022 - Elsevier
Cadmium (Cd), a heavy metal with strong carcinogenic properties has been linked with
breast cancer risk. Epidemiological data on the association between Cd exposure and …

Cellular mechanisms of zinc dysregulation: a perspective on zinc homeostasis as an etiological factor in the development and progression of breast cancer

S Alam, SL Kelleher - Nutrients, 2012 - mdpi.com
Worldwide, breast cancer is the most commonly diagnosed cancer among women and is the
leading cause of female cancer deaths. Zinc (Zn) functions as an antioxidant and plays a …

Metallothionein 2A expression is associated with cell proliferation in breast cancer

R Jin, VTK Chow, PH Tan, ST Dheen, W Duan… - …, 2002 - academic.oup.com
Metallothioneins (MTs) belong to a family of cysteine-rich, metal-binding intracellular
proteins, which have been linked with cell proliferation. In this study, expression levels of the …

Metallothionein expression in human neoplasia

SE Theocharis, AP Margeli, JT Klijanienko… - …, 2004 - Wiley Online Library
The metallothionein family is a class of low‐molecular‐weight, cysteine‐rich proteins with
high affinity for metal ions. Four major isoforms (metallothionein‐1,‐2,‐3, and‐4) have been …

Metallothionein in physiological and physiopathological processes

P Moffatt, F Denizeau - Drug metabolism reviews, 1997 - Taylor & Francis
Metallothioneins (MTs) are a family of small proteins having a molecular weight from 6 to 10
kDa. They are found throughout the animal kingdom, in plants, and in certain eukaryotic and …

Metallothionein–immunohistochemical cancer biomarker: a meta-analysis

J Gumulec, M Raudenska, V Adam, R Kizek… - PloS one, 2014 - journals.plos.org
Metallothionein (MT) has been extensively investigated as a molecular marker of various
types of cancer. In spite of the fact that numerous reviews have been published in this field …

Overexpression of resistance‐related proteins (metallothioneins, glutathione‐S‐transferase π, heat shock protein 27, and lung resistance‐related protein) in …

H Uozaki, H Horiuchi, T Ishida, T Iijima… - … Journal of the …, 1997 - Wiley Online Library
BACKGROUND The prognosis for patients with osteosarcoma has improved over the past
20 years, mainly due to developments in chemotherapy. Some proteins have been reported …

Metallothionein expression in human breast cancer

H Goulding, B Jasani, H Pereira, A Reid… - British journal of …, 1995 - nature.com
Metallothioneins are ubiquitous low molecular weight proteins characterised by high
cysteine content and affinity for binding heavy metals. Abnormal metallothionein function …

Over‐expression of metallothionein predicts chemoresistance in breast cancer

X Yap, HY Tan, J Huang, Y Lai… - The Journal of …, 2009 - Wiley Online Library
Metallothionein (MT) plays a role in fundamental cellular processes such as proliferation,
apoptosis and differentiation. We examined MT expression in women with invasive breast …