The diversity, composition, and function of the bacterial community inhabiting the human
gastrointestinal tract contributes to host health through its role in producing energy or …

Exosomes are small extracellular vesicles 40–160 nm in diameter that are secreted by
almost all cell types. Exosomes can carry diverse cargo including RNA, DNA, lipids …

Nonalcoholic fatty liver disease (NAFLD) is a major worldwide health problem. Recent
studies suggest that the gut microbiota influences NAFLD pathogenesis. Here, a murine …

The antioxidant tempol reduces obesity in mice. Here we show that tempol alters the gut
microbiome by preferentially reducing the genus Lactobacillus and its bile salt hydrolase …

The gut microbiota is associated with metabolic diseases including obesity, insulin
resistance, and nonalcoholic fatty liver disease, as shown by correlative studies and by …

Over one hundred different phospholipid molecular species are known to be present in
mammalian cells and tissues. Fatty acid remodeling systems for phospholipids including …

Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease
that can develop into cirrhosis, hepatic failure, and hepatocellular carcinoma. Although …

The gut microbiota is crucial in the regulation of bile acid (BA) metabolism. However, not
much is known about the regulation of BAs during progression to type 1 diabetes (T1D) …

Hepatocellular carcinoma (HCC) is a prevalent and aggressive liver malignancy. The
interplay between bile acids (BAs) and the gut microbiota has emerged as a critical factor in …

Cholestatic liver disease denotes any situation associated with impaired bile flow
concomitant with a noxious bile acid accumulation in the liver and/or systemic circulation …