The light sensor of vertebrate scotopic (low-light) vision, rhodopsin, is a G-protein-coupled
receptor comprising a polypeptide chain with bound chromophore, 11-cis-retinal, that …

G protein-coupled receptors (GPCRs) are the largest group of receptors involved in cellular
signaling across the plasma membrane and a major class of drug targets. The canonical …

Recent studies have shown that G protein coupled receptors (GPCRs) show selective and
promiscuous coupling to different Gα protein subfamilies and yet the mechanisms of the …

GPR84 is an orphan class AG protein-coupled receptor (GPCR) that is predominantly
expressed in immune cells and plays important roles in inflammation, fibrosis, and …

Chemokines are important protein-signaling molecules that regulate various immune
responses by activating chemokine receptors which belong to the G protein-coupled …

G protein-coupled receptors (GPCRs) regulate many cellular and physiological processes,
responding to a diverse range of extracellular stimuli including hormones, neurotransmitters …

The extracellular loop 2 (ECL2) is the longest and the most diverse loop among class AG
protein-coupled receptors (GPCRs). It connects the transmembrane (TM) helices 4 and 5 …

Corticotropin-releasing factor (CRF) and the three related peptides urocortins 1–3 (UCN1–
UCN3) are endocrine hormones that control the stress responses by activating CRF1R and …

G-protein βγ subunits are key participants in G-protein signaling. These subunits facilitate
interactions between receptors and G proteins that are critical for the G protein activation …

G protein-coupled receptors (GPCRs) couple to diverse heterotrimeric G protein subtypes
and then activate downstream signaling pathways in classical GPCR activation. It has also …