Inflammatory Arthritis is characterized by synovial proliferation, neovascularization and
leukocyte extravasation leading to joint destruction and functional disability. Efficiency of …

Background Reactive oxygen species-mediated cysteine sulfenic acid modification has
emerged as an important regulatory mechanism in cell signaling. The stability of sulfenic …

Many cellular redox reactions housed within mitochondria, peroxisomes and the
endoplasmic reticulum (ER) generate hydrogen peroxide (H2O2) and other reactive oxygen …

Oxygen metabolism is essential for sustaining aerobic life, and normal cellular homeostasis
works on a fine balance between the formation and elimination of reactive oxygen species …

Protein S‐glutathiolation, the reversible covalent addition of glutathione to cysteine residues
on target proteins, is emerging as a candidate mechanism by which both changes in the …

The enzymes involved in metabolism and signaling are regulated by posttranslational
modifications that influence their catalytic activity, rates of turnover, and targeting to …

In biological systems, the amino acid cysteine combines catalytic activity with an extensive
redox chemistry and unique metal binding properties. The interdependency of these three …

Reactive (low pKa) cysteine residues in proteins are critical components in redox signaling.
A particularly reactive and versatile reversibly oxidized form of cysteine, the sulfenic acid …

This review provides a comprehensive overview of the functional roles of disulfide bonds
and their relevance to human disease. The critical roles of disulfide bonds in protein …

The nuclear factor erythroid-derived 2 (NF-E2)-related factor 2 (Nrf2) is a transcription factor
well-known for its function in controlling the basal and inducible expression of a variety of …